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Clinical characteristics of hyperglycemic crises in patients without a history of diabetes

AIMS/INTRODUCTION: Hyperglycemic crises without a history of diabetes have not been well studied. We compared the clinical characteristics of patients with and without a history of diabetes, and evaluated the glycated hemoglobin levels. MATERIALS AND METHODS: Consecutive adult patients (aged >18 ...

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Autores principales: Chou, Willy, Chung, Min-Hsien, Wang, Hsien-Yi, Chen, Jiann-Hwa, Chen, Wei-Lung, Guo, How-Ran, Lin, Hung-Jung, Su, Shih-Bin, Huang, Chien-Cheng, Hsu, Chien-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234228/
https://www.ncbi.nlm.nih.gov/pubmed/25422765
http://dx.doi.org/10.1111/jdi.12209
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author Chou, Willy
Chung, Min-Hsien
Wang, Hsien-Yi
Chen, Jiann-Hwa
Chen, Wei-Lung
Guo, How-Ran
Lin, Hung-Jung
Su, Shih-Bin
Huang, Chien-Cheng
Hsu, Chien-Chin
author_facet Chou, Willy
Chung, Min-Hsien
Wang, Hsien-Yi
Chen, Jiann-Hwa
Chen, Wei-Lung
Guo, How-Ran
Lin, Hung-Jung
Su, Shih-Bin
Huang, Chien-Cheng
Hsu, Chien-Chin
author_sort Chou, Willy
collection PubMed
description AIMS/INTRODUCTION: Hyperglycemic crises without a history of diabetes have not been well studied. We compared the clinical characteristics of patients with and without a history of diabetes, and evaluated the glycated hemoglobin levels. MATERIALS AND METHODS: Consecutive adult patients (aged >18 years) visiting the emergency department (ED) between January 2004 and December 2010 were enrolled if they met the criteria for a hyperglycemic crisis. Patients were separated into those without and those with a history of diabetes. The 30-day mortality was the primary end-point. RESULTS: We enrolled 295 patients who made 330 visits to the ED. Patients without a history of diabetes made up 24.5% (81/330) of the hyperglycemic crises. Patients without a history of diabetes were more prone than patients with a history of diabetes to be younger and male, and to have better consciousness and renal function, more significant diabetic signs and symptoms (e.g., thirst, polydipsia, polyuria and bodyweight loss), higher blood sugar, and less opportunity of infection and mortality. Most of the patients (93.8%, 76/81) had glycated hemoglobin of ≥6.5%. CONCLUSIONS: The present study delineates the clinical characteristics of patients with hyperglycemic crises, but without a history of diabetes. Most patients had glycated hemoglobin ≥6.5%, which raises the argument of using this biomarker for routine screening of diabetes.
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spelling pubmed-42342282014-11-24 Clinical characteristics of hyperglycemic crises in patients without a history of diabetes Chou, Willy Chung, Min-Hsien Wang, Hsien-Yi Chen, Jiann-Hwa Chen, Wei-Lung Guo, How-Ran Lin, Hung-Jung Su, Shih-Bin Huang, Chien-Cheng Hsu, Chien-Chin J Diabetes Investig Articles AIMS/INTRODUCTION: Hyperglycemic crises without a history of diabetes have not been well studied. We compared the clinical characteristics of patients with and without a history of diabetes, and evaluated the glycated hemoglobin levels. MATERIALS AND METHODS: Consecutive adult patients (aged >18 years) visiting the emergency department (ED) between January 2004 and December 2010 were enrolled if they met the criteria for a hyperglycemic crisis. Patients were separated into those without and those with a history of diabetes. The 30-day mortality was the primary end-point. RESULTS: We enrolled 295 patients who made 330 visits to the ED. Patients without a history of diabetes made up 24.5% (81/330) of the hyperglycemic crises. Patients without a history of diabetes were more prone than patients with a history of diabetes to be younger and male, and to have better consciousness and renal function, more significant diabetic signs and symptoms (e.g., thirst, polydipsia, polyuria and bodyweight loss), higher blood sugar, and less opportunity of infection and mortality. Most of the patients (93.8%, 76/81) had glycated hemoglobin of ≥6.5%. CONCLUSIONS: The present study delineates the clinical characteristics of patients with hyperglycemic crises, but without a history of diabetes. Most patients had glycated hemoglobin ≥6.5%, which raises the argument of using this biomarker for routine screening of diabetes. BlackWell Publishing Ltd 2014-11 2014-03-05 /pmc/articles/PMC4234228/ /pubmed/25422765 http://dx.doi.org/10.1111/jdi.12209 Text en © 2014 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Chou, Willy
Chung, Min-Hsien
Wang, Hsien-Yi
Chen, Jiann-Hwa
Chen, Wei-Lung
Guo, How-Ran
Lin, Hung-Jung
Su, Shih-Bin
Huang, Chien-Cheng
Hsu, Chien-Chin
Clinical characteristics of hyperglycemic crises in patients without a history of diabetes
title Clinical characteristics of hyperglycemic crises in patients without a history of diabetes
title_full Clinical characteristics of hyperglycemic crises in patients without a history of diabetes
title_fullStr Clinical characteristics of hyperglycemic crises in patients without a history of diabetes
title_full_unstemmed Clinical characteristics of hyperglycemic crises in patients without a history of diabetes
title_short Clinical characteristics of hyperglycemic crises in patients without a history of diabetes
title_sort clinical characteristics of hyperglycemic crises in patients without a history of diabetes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234228/
https://www.ncbi.nlm.nih.gov/pubmed/25422765
http://dx.doi.org/10.1111/jdi.12209
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