Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni

Campylobacter jejuni is one of the most successful food-borne human pathogens. Here we use electron cryotomography to explore the ultrastructure of C. jejuni cells in logarithmically growing cultures. This provides the first look at this pathogen in a near-native state at macromolecular resolution (...

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Detalles Bibliográficos
Autores principales: Müller, Axel, Beeby, Morgan, McDowall, Alasdair W, Chow, Janet, Jensen, Grant J, Clemons, William M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234261/
https://www.ncbi.nlm.nih.gov/pubmed/25065852
http://dx.doi.org/10.1002/mbo3.200
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author Müller, Axel
Beeby, Morgan
McDowall, Alasdair W
Chow, Janet
Jensen, Grant J
Clemons, William M
author_facet Müller, Axel
Beeby, Morgan
McDowall, Alasdair W
Chow, Janet
Jensen, Grant J
Clemons, William M
author_sort Müller, Axel
collection PubMed
description Campylobacter jejuni is one of the most successful food-borne human pathogens. Here we use electron cryotomography to explore the ultrastructure of C. jejuni cells in logarithmically growing cultures. This provides the first look at this pathogen in a near-native state at macromolecular resolution (∼5 nm). We find a surprisingly complex polar architecture that includes ribosome exclusion zones, polyphosphate storage granules, extensive collar-shaped chemoreceptor arrays, and elaborate flagellar motors.
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spelling pubmed-42342612014-12-04 Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni Müller, Axel Beeby, Morgan McDowall, Alasdair W Chow, Janet Jensen, Grant J Clemons, William M Microbiologyopen Original Research Campylobacter jejuni is one of the most successful food-borne human pathogens. Here we use electron cryotomography to explore the ultrastructure of C. jejuni cells in logarithmically growing cultures. This provides the first look at this pathogen in a near-native state at macromolecular resolution (∼5 nm). We find a surprisingly complex polar architecture that includes ribosome exclusion zones, polyphosphate storage granules, extensive collar-shaped chemoreceptor arrays, and elaborate flagellar motors. BlackWell Publishing Ltd 2014-10 2014-07-25 /pmc/articles/PMC4234261/ /pubmed/25065852 http://dx.doi.org/10.1002/mbo3.200 Text en © 2014 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Müller, Axel
Beeby, Morgan
McDowall, Alasdair W
Chow, Janet
Jensen, Grant J
Clemons, William M
Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
title Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
title_full Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
title_fullStr Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
title_full_unstemmed Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
title_short Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
title_sort ultrastructure and complex polar architecture of the human pathogen campylobacter jejuni
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234261/
https://www.ncbi.nlm.nih.gov/pubmed/25065852
http://dx.doi.org/10.1002/mbo3.200
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