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Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study

BACKGROUND: Parental smoking and exposure of the mother or the child to environmental tobacco smoke (ETS) as risk factors for Acute non-Lymphocytic Leukemia (AnLL) were investigated. METHODS: Incident cases of childhood AnLL were enrolled in 14 Italian Regions during 1998–2001. We estimated odds rat...

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Autores principales: Mattioli, Stefano, Farioli, Andrea, Legittimo, Patrizia, Miligi, Lucia, Benvenuti, Alessandra, Ranucci, Alessandra, Salvan, Alberto, Rondelli, Roberto, Magnani, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234298/
https://www.ncbi.nlm.nih.gov/pubmed/25401754
http://dx.doi.org/10.1371/journal.pone.0111028
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author Mattioli, Stefano
Farioli, Andrea
Legittimo, Patrizia
Miligi, Lucia
Benvenuti, Alessandra
Ranucci, Alessandra
Salvan, Alberto
Rondelli, Roberto
Magnani, Corrado
author_facet Mattioli, Stefano
Farioli, Andrea
Legittimo, Patrizia
Miligi, Lucia
Benvenuti, Alessandra
Ranucci, Alessandra
Salvan, Alberto
Rondelli, Roberto
Magnani, Corrado
author_sort Mattioli, Stefano
collection PubMed
description BACKGROUND: Parental smoking and exposure of the mother or the child to environmental tobacco smoke (ETS) as risk factors for Acute non-Lymphocytic Leukemia (AnLL) were investigated. METHODS: Incident cases of childhood AnLL were enrolled in 14 Italian Regions during 1998–2001. We estimated odds ratios (OR) and 95% confidence intervals (95%CI) conducting logistic regression models including 82 cases of AnLL and 1,044 controls. Inverse probability weighting was applied adjusting for: age; sex; provenience; birth order; birth weight; breastfeeding; parental educational level age, birth year, and occupational exposure to benzene. RESULTS: Paternal smoke in the conception period was associated with AnLL (OR for ≥11 cigarettes/day  = 1.79, 95% CI 1.01–3.15; P trend 0.05). An apparent effect modification by maternal age was identified: only children of mothers aged below 30 presented increased risks. We found weak statistical evidence of an association of AnLL with maternal exposure to ETS (OR for exposure>3 hours/day  = 1.85, 95%CI 0.97–3.52; P trend 0.07). No association was observed between AnLL and either maternal smoking during pregnancy or child exposure to ETS. CONCLUSIONS: This study is consistent with the hypothesis that paternal smoke is associated with AnLL. We observed statistical evidence of an association between maternal exposure to ETS and AnLL, but believe bias might have inflated our estimates.
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spelling pubmed-42342982014-11-21 Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study Mattioli, Stefano Farioli, Andrea Legittimo, Patrizia Miligi, Lucia Benvenuti, Alessandra Ranucci, Alessandra Salvan, Alberto Rondelli, Roberto Magnani, Corrado PLoS One Research Article BACKGROUND: Parental smoking and exposure of the mother or the child to environmental tobacco smoke (ETS) as risk factors for Acute non-Lymphocytic Leukemia (AnLL) were investigated. METHODS: Incident cases of childhood AnLL were enrolled in 14 Italian Regions during 1998–2001. We estimated odds ratios (OR) and 95% confidence intervals (95%CI) conducting logistic regression models including 82 cases of AnLL and 1,044 controls. Inverse probability weighting was applied adjusting for: age; sex; provenience; birth order; birth weight; breastfeeding; parental educational level age, birth year, and occupational exposure to benzene. RESULTS: Paternal smoke in the conception period was associated with AnLL (OR for ≥11 cigarettes/day  = 1.79, 95% CI 1.01–3.15; P trend 0.05). An apparent effect modification by maternal age was identified: only children of mothers aged below 30 presented increased risks. We found weak statistical evidence of an association of AnLL with maternal exposure to ETS (OR for exposure>3 hours/day  = 1.85, 95%CI 0.97–3.52; P trend 0.07). No association was observed between AnLL and either maternal smoking during pregnancy or child exposure to ETS. CONCLUSIONS: This study is consistent with the hypothesis that paternal smoke is associated with AnLL. We observed statistical evidence of an association between maternal exposure to ETS and AnLL, but believe bias might have inflated our estimates. Public Library of Science 2014-11-17 /pmc/articles/PMC4234298/ /pubmed/25401754 http://dx.doi.org/10.1371/journal.pone.0111028 Text en © 2014 Mattioli et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mattioli, Stefano
Farioli, Andrea
Legittimo, Patrizia
Miligi, Lucia
Benvenuti, Alessandra
Ranucci, Alessandra
Salvan, Alberto
Rondelli, Roberto
Magnani, Corrado
Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study
title Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study
title_full Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study
title_fullStr Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study
title_full_unstemmed Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study
title_short Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study
title_sort tobacco smoke and risk of childhood acute non-lymphocytic leukemia: findings from the setil study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234298/
https://www.ncbi.nlm.nih.gov/pubmed/25401754
http://dx.doi.org/10.1371/journal.pone.0111028
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