Cargando…

Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival

BACKGROUND: Ephrin (Eph) receptors are frequently overexpressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, metastasis and angiogenesis. The present study aimed to evaluate the clinical significance of EphA1, A4, A5 and A7 protein expression in non-smal...

Descripción completa

Detalles Bibliográficos
Autores principales: Giaginis, Constantinos, Tsoukalas, Nikolaos, Bournakis, Evangelos, Alexandrou, Paraskevi, Kavantzas, Nikolaos, Patsouris, Efstratios, Theocharis, Stamatios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234387/
https://www.ncbi.nlm.nih.gov/pubmed/24495444
http://dx.doi.org/10.1186/1472-6890-14-8
_version_ 1782344848760635392
author Giaginis, Constantinos
Tsoukalas, Nikolaos
Bournakis, Evangelos
Alexandrou, Paraskevi
Kavantzas, Nikolaos
Patsouris, Efstratios
Theocharis, Stamatios
author_facet Giaginis, Constantinos
Tsoukalas, Nikolaos
Bournakis, Evangelos
Alexandrou, Paraskevi
Kavantzas, Nikolaos
Patsouris, Efstratios
Theocharis, Stamatios
author_sort Giaginis, Constantinos
collection PubMed
description BACKGROUND: Ephrin (Eph) receptors are frequently overexpressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, metastasis and angiogenesis. The present study aimed to evaluate the clinical significance of EphA1, A4, A5 and A7 protein expression in non-small cell lung carcinoma (NSCLC). METHODS: EphA1, A4, A5 and A7 protein expression was assessed immunohistochemically in tissue microarrays of 88 surgically resected NSCLC and was analyzed in relation with clinicopathological characteristics and patients’ survival. RESULTS: Elevated EphA4 expression was significantly associated with low histopathological stage and presence of inflammation (p = 0.047 and p = 0.026, respectively). Elevated EphA7 expression was significantly associated with older patients’ age, presence of fibrosis and smaller tumor size (p = 0.036, p = 0.029 and p = 0.018, respectively). EphA1, A5 and A7 expression were positively associated with tumor proliferative capacity (p = 0.047, p = 0.002 and p = 0.046, respectively). Elevated EphA4, A5 and A7 expression were identified as predictors of favourable patients’ survival at both univariate (Log-rank test, 0 = 0.019, p = 0.006 and p = 0.012, respectively) and multivariate levels (Cox-regression analysis, p = 0.029, p = 0.068 and p = 0.044, respectively). CONCLUSIONS: The present study supported evidence that Ephs may be involved in lung cancer progression, reinforcing their utility as clinical biomarkers for patients’ management and prognosis, as also as potential targets for future therapeutic interventions.
format Online
Article
Text
id pubmed-4234387
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-42343872014-11-18 Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival Giaginis, Constantinos Tsoukalas, Nikolaos Bournakis, Evangelos Alexandrou, Paraskevi Kavantzas, Nikolaos Patsouris, Efstratios Theocharis, Stamatios BMC Clin Pathol Research Article BACKGROUND: Ephrin (Eph) receptors are frequently overexpressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, metastasis and angiogenesis. The present study aimed to evaluate the clinical significance of EphA1, A4, A5 and A7 protein expression in non-small cell lung carcinoma (NSCLC). METHODS: EphA1, A4, A5 and A7 protein expression was assessed immunohistochemically in tissue microarrays of 88 surgically resected NSCLC and was analyzed in relation with clinicopathological characteristics and patients’ survival. RESULTS: Elevated EphA4 expression was significantly associated with low histopathological stage and presence of inflammation (p = 0.047 and p = 0.026, respectively). Elevated EphA7 expression was significantly associated with older patients’ age, presence of fibrosis and smaller tumor size (p = 0.036, p = 0.029 and p = 0.018, respectively). EphA1, A5 and A7 expression were positively associated with tumor proliferative capacity (p = 0.047, p = 0.002 and p = 0.046, respectively). Elevated EphA4, A5 and A7 expression were identified as predictors of favourable patients’ survival at both univariate (Log-rank test, 0 = 0.019, p = 0.006 and p = 0.012, respectively) and multivariate levels (Cox-regression analysis, p = 0.029, p = 0.068 and p = 0.044, respectively). CONCLUSIONS: The present study supported evidence that Ephs may be involved in lung cancer progression, reinforcing their utility as clinical biomarkers for patients’ management and prognosis, as also as potential targets for future therapeutic interventions. BioMed Central 2014-02-04 /pmc/articles/PMC4234387/ /pubmed/24495444 http://dx.doi.org/10.1186/1472-6890-14-8 Text en Copyright © 2014 Giaginis et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Giaginis, Constantinos
Tsoukalas, Nikolaos
Bournakis, Evangelos
Alexandrou, Paraskevi
Kavantzas, Nikolaos
Patsouris, Efstratios
Theocharis, Stamatios
Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival
title Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival
title_full Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival
title_fullStr Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival
title_full_unstemmed Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival
title_short Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival
title_sort ephrin (eph) receptor a1, a4, a5 and a7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234387/
https://www.ncbi.nlm.nih.gov/pubmed/24495444
http://dx.doi.org/10.1186/1472-6890-14-8
work_keys_str_mv AT giaginisconstantinos ephrinephreceptora1a4a5anda7expressioninhumannonsmallcelllungcarcinomaassociationswithclinicopathologicalparameterstumorproliferativecapacityandpatientssurvival
AT tsoukalasnikolaos ephrinephreceptora1a4a5anda7expressioninhumannonsmallcelllungcarcinomaassociationswithclinicopathologicalparameterstumorproliferativecapacityandpatientssurvival
AT bournakisevangelos ephrinephreceptora1a4a5anda7expressioninhumannonsmallcelllungcarcinomaassociationswithclinicopathologicalparameterstumorproliferativecapacityandpatientssurvival
AT alexandrouparaskevi ephrinephreceptora1a4a5anda7expressioninhumannonsmallcelllungcarcinomaassociationswithclinicopathologicalparameterstumorproliferativecapacityandpatientssurvival
AT kavantzasnikolaos ephrinephreceptora1a4a5anda7expressioninhumannonsmallcelllungcarcinomaassociationswithclinicopathologicalparameterstumorproliferativecapacityandpatientssurvival
AT patsourisefstratios ephrinephreceptora1a4a5anda7expressioninhumannonsmallcelllungcarcinomaassociationswithclinicopathologicalparameterstumorproliferativecapacityandpatientssurvival
AT theocharisstamatios ephrinephreceptora1a4a5anda7expressioninhumannonsmallcelllungcarcinomaassociationswithclinicopathologicalparameterstumorproliferativecapacityandpatientssurvival