CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

[Image: see text] We have recently identified 1,8-naphthyridin-2(1H)-one-3-carboxamide as a new scaffold very suitable for the development of new CB2 receptor potent and selective ligands. In this paper we describe a number of additional derivatives in which the same central scaffold has been variou...

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Detalles Bibliográficos
Autores principales: Lucchesi, Valentina, Hurst, Dow P., Shore, Derek M., Bertini, Simone, Ehrmann, Brandie M., Allarà, Marco, Lawrence, Lyle, Ligresti, Alessia, Minutolo, Filippo, Saccomanni, Giuseppe, Sharir, Haleli, Macchia, Marco, Di Marzo, Vincenzo, Abood, Mary E., Reggio, Patricia H., Manera, Clementina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234427/
https://www.ncbi.nlm.nih.gov/pubmed/25272206
http://dx.doi.org/10.1021/jm500807e

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