Dendritic Cells Control Fibroblastic Reticular Network Tension and Lymph Node Expansion

Following immunogenic challenge, infiltrating and dividing lymphocytes significantly increase lymph node (LN) cellularity leading to organ expansion(1,2). Here we report that the physical elasticity of LNs is maintained in part by podoplanin (PDPN) signalling in stromal fibroblastic reticular cells...

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Detalles Bibliográficos
Autores principales: Acton, Sophie E., Farrugia, Aaron J., Astarita, Jillian L., Mourão-Sá, Diego, Jenkins, Robert P., Nye, Emma, Hooper, Steven, van Blijswijk, Janneke, Rogers, Neil C., Snelgrove, Kathryn J., Rosewell, Ian, Moita, Luis F., Stamp, Gordon, Turley, Shannon J., Sahai, Erik, Sousa, Caetano Reis e
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235005/
https://www.ncbi.nlm.nih.gov/pubmed/25341788
http://dx.doi.org/10.1038/nature13814

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