Sensitivity of a point of care tick-test for the development of Lyme borreliosis

BACKGROUND: A commercially available self-test for the detection of Borrelia burgdorferi sensu lato in ticks was evaluated for its ability to predict erythema migrans formation. FINDINGS: The self-test was performed on 127 Ixodes ricinus from 122 humans that reported tick bites at enrolment and occu...

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Detalles Bibliográficos
Autores principales: Sprong, Hein, Docters van Leeuwen, Arieke, Fonville, Manoj, Harms, Margriet, van Vliet, Arnold J, van Pelt, Wilfrid, Ferreira, José A, van den Wijngaard, Cees C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235040/
https://www.ncbi.nlm.nih.gov/pubmed/24304944
http://dx.doi.org/10.1186/1756-3305-6-338
Descripción
Sumario:BACKGROUND: A commercially available self-test for the detection of Borrelia burgdorferi sensu lato in ticks was evaluated for its ability to predict erythema migrans formation. FINDINGS: The self-test was performed on 127 Ixodes ricinus from 122 humans that reported tick bites at enrolment and occurrence of symptoms during follow-up. The self-test gave negative results on all the 122 individuals, 14 of whom reported erythema migrans (EM) at follow-up of which 10 were confirmed by their GP. The estimated sensitivity of the self-test for prediction of EM formation is 0% (95% CI: 0%-28%). CONCLUSIONS: This self-test is not suitable for reducing the number needed to treat in a post-exposure prophylaxis setting as it already missed all the obvious early Lyme borreliosis cases.

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