Diagnosis and Subclassification of Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a disseminated malignancy of B- or T-lymphoblasts which imposes a rapid and accurate diagnostic process to support an optimal risk-oriented therapy and thus increase the curability rate. The need for a precise diagnostic algorithm is underlined by the awareness...

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Detalles Bibliográficos
Autores principales: Chiaretti, Sabina, Zini, Gina, Bassan, Renato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235437/
https://www.ncbi.nlm.nih.gov/pubmed/25408859
http://dx.doi.org/10.4084/MJHID.2014.073
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author Chiaretti, Sabina
Zini, Gina
Bassan, Renato
author_facet Chiaretti, Sabina
Zini, Gina
Bassan, Renato
author_sort Chiaretti, Sabina
collection PubMed
description Acute lymphoblastic leukemia (ALL) is a disseminated malignancy of B- or T-lymphoblasts which imposes a rapid and accurate diagnostic process to support an optimal risk-oriented therapy and thus increase the curability rate. The need for a precise diagnostic algorithm is underlined by the awareness that both ALL therapy and related success rates may vary greatly between ALL subsets, from standard chemotherapy in patients with standard-risk ALL, to allotransplantation (SCT) and targeted therapy in high-risk patients and cases expressing suitable biological targets, respectively. This review summarizes how best to identify ALL and the most relevant ALL subsets.
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spelling pubmed-42354372014-11-18 Diagnosis and Subclassification of Acute Lymphoblastic Leukemia Chiaretti, Sabina Zini, Gina Bassan, Renato Mediterr J Hematol Infect Dis Review Article Acute lymphoblastic leukemia (ALL) is a disseminated malignancy of B- or T-lymphoblasts which imposes a rapid and accurate diagnostic process to support an optimal risk-oriented therapy and thus increase the curability rate. The need for a precise diagnostic algorithm is underlined by the awareness that both ALL therapy and related success rates may vary greatly between ALL subsets, from standard chemotherapy in patients with standard-risk ALL, to allotransplantation (SCT) and targeted therapy in high-risk patients and cases expressing suitable biological targets, respectively. This review summarizes how best to identify ALL and the most relevant ALL subsets. Università Cattolica del Sacro Cuore 2014-11-01 /pmc/articles/PMC4235437/ /pubmed/25408859 http://dx.doi.org/10.4084/MJHID.2014.073 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chiaretti, Sabina
Zini, Gina
Bassan, Renato
Diagnosis and Subclassification of Acute Lymphoblastic Leukemia
title Diagnosis and Subclassification of Acute Lymphoblastic Leukemia
title_full Diagnosis and Subclassification of Acute Lymphoblastic Leukemia
title_fullStr Diagnosis and Subclassification of Acute Lymphoblastic Leukemia
title_full_unstemmed Diagnosis and Subclassification of Acute Lymphoblastic Leukemia
title_short Diagnosis and Subclassification of Acute Lymphoblastic Leukemia
title_sort diagnosis and subclassification of acute lymphoblastic leukemia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235437/
https://www.ncbi.nlm.nih.gov/pubmed/25408859
http://dx.doi.org/10.4084/MJHID.2014.073
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