Polyethylene glycol–polylactic acid nanoparticles modified with cysteine–arginine–glutamic acid–lysine–alanine fibrin-homing peptide for glioblastoma therapy by enhanced retention effect

For a nanoparticulate drug-delivery system, crucial challenges in brain-glioblastoma therapy are its poor penetration and retention in the glioblastoma parenchyma. As a prevailing component in the extracellular matrix of many solid tumors, fibrin plays a critical role in the maintenance of glioblast...

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Detalles Bibliográficos
Autores principales: Wu, Junzhu, Zhao, Jingjing, Zhang, Bo, Qian, Yong, Gao, Huile, Yu, Yuan, Wei, Yan, Yang, Zhi, Jiang, Xinguo, Pang, Zhiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235507/
https://www.ncbi.nlm.nih.gov/pubmed/25419130
http://dx.doi.org/10.2147/IJN.S72649

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