Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm. We found that aging was accompanied by increases in visceral fat similar to that seen i...

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Detalles Bibliográficos
Autores principales: Mirsoian, Annie, Bouchlaka, Myriam N., Sckisel, Gail D., Chen, Mingyi, Pai, Chien-Chun Steven, Maverakis, Emanuel, Spencer, Richard G., Fishbein, Kenneth W., Siddiqui, Sana, Monjazeb, Arta M., Martin, Bronwen, Maudsley, Stuart, Hesdorffer, Charles, Ferrucci, Luigi, Longo, Dan L., Blazar, Bruce R., Wiltrout, Robert H., Taub, Dennis D., Murphy, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235633/
https://www.ncbi.nlm.nih.gov/pubmed/25366964
http://dx.doi.org/10.1084/jem.20140116

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