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Sex steroid blockade enhances thymopoiesis by modulating Notch signaling

Paradoxical to its importance for generating a diverse T cell repertoire, thymic function progressively declines throughout life. This process has been at least partially attributed to the effects of sex steroids, and their removal promotes enhanced thymopoiesis and recovery from immune injury. We s...

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Detalles Bibliográficos
Autores principales:	Velardi, Enrico, Tsai, Jennifer J., Holland, Amanda M., Wertheimer, Tobias, Yu, Vionnie W.C., Zakrzewski, Johannes L., Tuckett, Andrea Z., Singer, Natalie V., West, Mallory L., Smith, Odette M., Young, Lauren F., Kreines, Fabiana M., Levy, Emily R., Boyd, Richard L., Scadden, David T., Dudakov, Jarrod A., van den Brink, Marcel R.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235646/ https://www.ncbi.nlm.nih.gov/pubmed/25332287 http://dx.doi.org/10.1084/jem.20131289

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