Hypomethylation and Over-Expression of the Beta Isoform of BLIMP1 is Induced by Epstein-Barr Virus Infection of B Cells; Potential Implications for the Pathogenesis of EBV-Associated Lymphomas

B-lymphocyte-induced maturation protein 1 (BLIMP1) exists as two major isoforms, α and β, which arise from alternate promoters. Inactivation of the full length BLIMP1α isoform is thought to contribute to B cell lymphomagenesis by blocking post-germinal centre (GC) B cell differentiation. In contrast...

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Detalles Bibliográficos
Autores principales: Vrzalikova, Katerina, Leonard, Sarah, Fan, Yichao, Bell, Andrew, Vockerodt, Martina, Flodr, Patrik, Wright, Kenneth L., Rowe, Martin, Tao, Qian, Murray, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235687/
https://www.ncbi.nlm.nih.gov/pubmed/25436766
http://dx.doi.org/10.3390/pathogens1020083

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