The Functional Role of Prion Protein (PrP(C)) on Autophagy

Cellular prion protein (PrP(C)) plays an important role in the cellular defense against oxidative stress. However, the exact protective mechanism of PrP(C) is unclear. Autophagy is essential for survival, differentiation, development, and homeostasis in several organisms. Although the role that autophagy plays in neurodegenerative disease has yet to be established, it is clear that autophagy-induced cell death is observed in neurodegenerative disorders that exhibit protein aggregations. Moreover, autophagy can promote cell survival and cell death under various conditions. In this review, we describe the involvement of autophagy in prion disease and the effects of PrP(C).