Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction

Kuru, the first human transmissible spongiform encephalopathy was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, I briefly summarize the history of this seminal discovery along its epidemiology, clinical picture, neuropathology and molecular genetics. The discovery o...

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Autor principal: Liberski, Pawel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235695/
https://www.ncbi.nlm.nih.gov/pubmed/25437203
http://dx.doi.org/10.3390/pathogens2030472
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author Liberski, Pawel P.
author_facet Liberski, Pawel P.
author_sort Liberski, Pawel P.
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description Kuru, the first human transmissible spongiform encephalopathy was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, I briefly summarize the history of this seminal discovery along its epidemiology, clinical picture, neuropathology and molecular genetics. The discovery of kuru opened new windows into the realms of human medicine and was instrumental in the later transmission of Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century.
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spelling pubmed-42356952014-11-25 Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction Liberski, Pawel P. Pathogens Review Kuru, the first human transmissible spongiform encephalopathy was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, I briefly summarize the history of this seminal discovery along its epidemiology, clinical picture, neuropathology and molecular genetics. The discovery of kuru opened new windows into the realms of human medicine and was instrumental in the later transmission of Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century. MDPI 2013-07-18 /pmc/articles/PMC4235695/ /pubmed/25437203 http://dx.doi.org/10.3390/pathogens2030472 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Liberski, Pawel P.
Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction
title Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction
title_full Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction
title_fullStr Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction
title_full_unstemmed Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction
title_short Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction
title_sort kuru: a journey back in time from papua new guinea to the neanderthals’ extinction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235695/
https://www.ncbi.nlm.nih.gov/pubmed/25437203
http://dx.doi.org/10.3390/pathogens2030472
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