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Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy

Successful transmission of Transmissible Mink Encephalopathy (TME) to cattle supports the bovine hypothesis for the still controversial origin of TME outbreaks. Human and primate susceptibility to classical Bovine Spongiform Encephalopathy (c-BSE) and the transmissibility of L-type BSE to macaques i...

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Autores principales: Comoy, Emmanuel E., Mikol, Jacqueline, Ruchoux, Marie-Madeleine, Durand, Valérie, Luccantoni-Freire, Sophie, Dehen, Capucine, Correia, Evelyne, Casalone, Cristina, Richt, Juergen A., Greenlee, Justin J., Torres, Juan Maria, Brown, Paul, Deslys, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235697/
https://www.ncbi.nlm.nih.gov/pubmed/25437205
http://dx.doi.org/10.3390/pathogens2030520
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author Comoy, Emmanuel E.
Mikol, Jacqueline
Ruchoux, Marie-Madeleine
Durand, Valérie
Luccantoni-Freire, Sophie
Dehen, Capucine
Correia, Evelyne
Casalone, Cristina
Richt, Juergen A.
Greenlee, Justin J.
Torres, Juan Maria
Brown, Paul
Deslys, Jean-Philippe
author_facet Comoy, Emmanuel E.
Mikol, Jacqueline
Ruchoux, Marie-Madeleine
Durand, Valérie
Luccantoni-Freire, Sophie
Dehen, Capucine
Correia, Evelyne
Casalone, Cristina
Richt, Juergen A.
Greenlee, Justin J.
Torres, Juan Maria
Brown, Paul
Deslys, Jean-Philippe
author_sort Comoy, Emmanuel E.
collection PubMed
description Successful transmission of Transmissible Mink Encephalopathy (TME) to cattle supports the bovine hypothesis for the still controversial origin of TME outbreaks. Human and primate susceptibility to classical Bovine Spongiform Encephalopathy (c-BSE) and the transmissibility of L-type BSE to macaques indicate a low cattle-to-primate species barrier. We therefore evaluated the zoonotic potential of cattle-adapted TME. In less than two years, this strain induced in cynomolgus macaques a neurological disease similar to L-BSE but distinct from c-BSE. TME derived from another donor species (raccoon) induced a similar disease with even shorter incubation periods. L-BSE and cattle-adapted TME were also transmissible to transgenic mice expressing human prion protein (PrP). Secondary transmissions to transgenic mice expressing bovine PrP maintained the features of the three tested bovine strains (cattle TME, c-BSE and L-BSE) regardless of intermediate host. Thus, TME is the third animal prion strain transmissible to both macaques and humanized transgenic mice, suggesting zoonotic potentials that should be considered in the risk analysis of animal prion diseases for human health. Moreover, the similarities between TME and L-BSE are highly suggestive of a link between these strains, and therefore the possible presence of L-BSE for many decades prior to its identification in USA and Europe.
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spelling pubmed-42356972014-11-25 Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy Comoy, Emmanuel E. Mikol, Jacqueline Ruchoux, Marie-Madeleine Durand, Valérie Luccantoni-Freire, Sophie Dehen, Capucine Correia, Evelyne Casalone, Cristina Richt, Juergen A. Greenlee, Justin J. Torres, Juan Maria Brown, Paul Deslys, Jean-Philippe Pathogens Article Successful transmission of Transmissible Mink Encephalopathy (TME) to cattle supports the bovine hypothesis for the still controversial origin of TME outbreaks. Human and primate susceptibility to classical Bovine Spongiform Encephalopathy (c-BSE) and the transmissibility of L-type BSE to macaques indicate a low cattle-to-primate species barrier. We therefore evaluated the zoonotic potential of cattle-adapted TME. In less than two years, this strain induced in cynomolgus macaques a neurological disease similar to L-BSE but distinct from c-BSE. TME derived from another donor species (raccoon) induced a similar disease with even shorter incubation periods. L-BSE and cattle-adapted TME were also transmissible to transgenic mice expressing human prion protein (PrP). Secondary transmissions to transgenic mice expressing bovine PrP maintained the features of the three tested bovine strains (cattle TME, c-BSE and L-BSE) regardless of intermediate host. Thus, TME is the third animal prion strain transmissible to both macaques and humanized transgenic mice, suggesting zoonotic potentials that should be considered in the risk analysis of animal prion diseases for human health. Moreover, the similarities between TME and L-BSE are highly suggestive of a link between these strains, and therefore the possible presence of L-BSE for many decades prior to its identification in USA and Europe. MDPI 2013-07-30 /pmc/articles/PMC4235697/ /pubmed/25437205 http://dx.doi.org/10.3390/pathogens2030520 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Comoy, Emmanuel E.
Mikol, Jacqueline
Ruchoux, Marie-Madeleine
Durand, Valérie
Luccantoni-Freire, Sophie
Dehen, Capucine
Correia, Evelyne
Casalone, Cristina
Richt, Juergen A.
Greenlee, Justin J.
Torres, Juan Maria
Brown, Paul
Deslys, Jean-Philippe
Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
title Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
title_full Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
title_fullStr Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
title_full_unstemmed Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
title_short Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
title_sort evaluation of the zoonotic potential of transmissible mink encephalopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235697/
https://www.ncbi.nlm.nih.gov/pubmed/25437205
http://dx.doi.org/10.3390/pathogens2030520
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