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The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus

Objectives. To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in Systemic Lupus Erythematosus (SLE). Methods. Sixty-nine SLE patients, complaining of joint symptoms, and 44 rheumatoid arthritis (RA) patients were enrolled. In SLE patients disease activity w...

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Autores principales: Ceccarelli, Fulvia, Perricone, Carlo, Massaro, Laura, Pacucci, Viviana Antonella, Cipriano, Enrica, Truglia, Simona, Miranda, Francesca, Spinelli, Francesca Romana, Alessandri, Cristiano, Valesini, Guido, Conti, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235977/
https://www.ncbi.nlm.nih.gov/pubmed/25530992
http://dx.doi.org/10.1155/2014/236842
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author Ceccarelli, Fulvia
Perricone, Carlo
Massaro, Laura
Pacucci, Viviana Antonella
Cipriano, Enrica
Truglia, Simona
Miranda, Francesca
Spinelli, Francesca Romana
Alessandri, Cristiano
Valesini, Guido
Conti, Fabrizio
author_facet Ceccarelli, Fulvia
Perricone, Carlo
Massaro, Laura
Pacucci, Viviana Antonella
Cipriano, Enrica
Truglia, Simona
Miranda, Francesca
Spinelli, Francesca Romana
Alessandri, Cristiano
Valesini, Guido
Conti, Fabrizio
author_sort Ceccarelli, Fulvia
collection PubMed
description Objectives. To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in Systemic Lupus Erythematosus (SLE). Methods. Sixty-nine SLE patients, complaining of joint symptoms, and 44 rheumatoid arthritis (RA) patients were enrolled. In SLE patients disease activity was assessed with SLEDAI-2K. DAS28 was calculated in all the patients. Results. Thirty SLE patients (43.5%) showed clinical signs of arthritis. Mean DAS28 was 4.0 ± 1.4, 22 patients (31.9%) had low disease activity, 29 (42.0%) moderate, and 18 (26.1%) high. We dichotomized SLE patients according to the presence (Group 1) or absence (Group 2) of articular involvement according to SLEDAI-2K: 56.3% of the patients of the second group had a moderate/high activity according to DAS28. We compared SLE patients with 44 RA patients (M/F 9/35, mean age 55.6 ± 14.5 years; mean disease duration 140.4 ± 105.6 months). No significant differences were found regarding the values of DAS28 between SLE and RA patients. On the contrary, the values of tender and swollen joint count were significantly higher in RA compared to SLE patients (P = 0.0002 and P = 0.0001, resp.). Conclusions. We suggest the use of the DAS28 in the assessment of joint involvement in SLE patients.
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spelling pubmed-42359772014-12-21 The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus Ceccarelli, Fulvia Perricone, Carlo Massaro, Laura Pacucci, Viviana Antonella Cipriano, Enrica Truglia, Simona Miranda, Francesca Spinelli, Francesca Romana Alessandri, Cristiano Valesini, Guido Conti, Fabrizio ScientificWorldJournal Clinical Study Objectives. To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in Systemic Lupus Erythematosus (SLE). Methods. Sixty-nine SLE patients, complaining of joint symptoms, and 44 rheumatoid arthritis (RA) patients were enrolled. In SLE patients disease activity was assessed with SLEDAI-2K. DAS28 was calculated in all the patients. Results. Thirty SLE patients (43.5%) showed clinical signs of arthritis. Mean DAS28 was 4.0 ± 1.4, 22 patients (31.9%) had low disease activity, 29 (42.0%) moderate, and 18 (26.1%) high. We dichotomized SLE patients according to the presence (Group 1) or absence (Group 2) of articular involvement according to SLEDAI-2K: 56.3% of the patients of the second group had a moderate/high activity according to DAS28. We compared SLE patients with 44 RA patients (M/F 9/35, mean age 55.6 ± 14.5 years; mean disease duration 140.4 ± 105.6 months). No significant differences were found regarding the values of DAS28 between SLE and RA patients. On the contrary, the values of tender and swollen joint count were significantly higher in RA compared to SLE patients (P = 0.0002 and P = 0.0001, resp.). Conclusions. We suggest the use of the DAS28 in the assessment of joint involvement in SLE patients. Hindawi Publishing Corporation 2014 2014-11-03 /pmc/articles/PMC4235977/ /pubmed/25530992 http://dx.doi.org/10.1155/2014/236842 Text en Copyright © 2014 Fulvia Ceccarelli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Ceccarelli, Fulvia
Perricone, Carlo
Massaro, Laura
Pacucci, Viviana Antonella
Cipriano, Enrica
Truglia, Simona
Miranda, Francesca
Spinelli, Francesca Romana
Alessandri, Cristiano
Valesini, Guido
Conti, Fabrizio
The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus
title The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus
title_full The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus
title_fullStr The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus
title_full_unstemmed The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus
title_short The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus
title_sort role of disease activity score 28 in the evaluation of articular involvement in systemic lupus erythematosus
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235977/
https://www.ncbi.nlm.nih.gov/pubmed/25530992
http://dx.doi.org/10.1155/2014/236842
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