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The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus
Objectives. To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in Systemic Lupus Erythematosus (SLE). Methods. Sixty-nine SLE patients, complaining of joint symptoms, and 44 rheumatoid arthritis (RA) patients were enrolled. In SLE patients disease activity w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235977/ https://www.ncbi.nlm.nih.gov/pubmed/25530992 http://dx.doi.org/10.1155/2014/236842 |
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author | Ceccarelli, Fulvia Perricone, Carlo Massaro, Laura Pacucci, Viviana Antonella Cipriano, Enrica Truglia, Simona Miranda, Francesca Spinelli, Francesca Romana Alessandri, Cristiano Valesini, Guido Conti, Fabrizio |
author_facet | Ceccarelli, Fulvia Perricone, Carlo Massaro, Laura Pacucci, Viviana Antonella Cipriano, Enrica Truglia, Simona Miranda, Francesca Spinelli, Francesca Romana Alessandri, Cristiano Valesini, Guido Conti, Fabrizio |
author_sort | Ceccarelli, Fulvia |
collection | PubMed |
description | Objectives. To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in Systemic Lupus Erythematosus (SLE). Methods. Sixty-nine SLE patients, complaining of joint symptoms, and 44 rheumatoid arthritis (RA) patients were enrolled. In SLE patients disease activity was assessed with SLEDAI-2K. DAS28 was calculated in all the patients. Results. Thirty SLE patients (43.5%) showed clinical signs of arthritis. Mean DAS28 was 4.0 ± 1.4, 22 patients (31.9%) had low disease activity, 29 (42.0%) moderate, and 18 (26.1%) high. We dichotomized SLE patients according to the presence (Group 1) or absence (Group 2) of articular involvement according to SLEDAI-2K: 56.3% of the patients of the second group had a moderate/high activity according to DAS28. We compared SLE patients with 44 RA patients (M/F 9/35, mean age 55.6 ± 14.5 years; mean disease duration 140.4 ± 105.6 months). No significant differences were found regarding the values of DAS28 between SLE and RA patients. On the contrary, the values of tender and swollen joint count were significantly higher in RA compared to SLE patients (P = 0.0002 and P = 0.0001, resp.). Conclusions. We suggest the use of the DAS28 in the assessment of joint involvement in SLE patients. |
format | Online Article Text |
id | pubmed-4235977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42359772014-12-21 The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus Ceccarelli, Fulvia Perricone, Carlo Massaro, Laura Pacucci, Viviana Antonella Cipriano, Enrica Truglia, Simona Miranda, Francesca Spinelli, Francesca Romana Alessandri, Cristiano Valesini, Guido Conti, Fabrizio ScientificWorldJournal Clinical Study Objectives. To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in Systemic Lupus Erythematosus (SLE). Methods. Sixty-nine SLE patients, complaining of joint symptoms, and 44 rheumatoid arthritis (RA) patients were enrolled. In SLE patients disease activity was assessed with SLEDAI-2K. DAS28 was calculated in all the patients. Results. Thirty SLE patients (43.5%) showed clinical signs of arthritis. Mean DAS28 was 4.0 ± 1.4, 22 patients (31.9%) had low disease activity, 29 (42.0%) moderate, and 18 (26.1%) high. We dichotomized SLE patients according to the presence (Group 1) or absence (Group 2) of articular involvement according to SLEDAI-2K: 56.3% of the patients of the second group had a moderate/high activity according to DAS28. We compared SLE patients with 44 RA patients (M/F 9/35, mean age 55.6 ± 14.5 years; mean disease duration 140.4 ± 105.6 months). No significant differences were found regarding the values of DAS28 between SLE and RA patients. On the contrary, the values of tender and swollen joint count were significantly higher in RA compared to SLE patients (P = 0.0002 and P = 0.0001, resp.). Conclusions. We suggest the use of the DAS28 in the assessment of joint involvement in SLE patients. Hindawi Publishing Corporation 2014 2014-11-03 /pmc/articles/PMC4235977/ /pubmed/25530992 http://dx.doi.org/10.1155/2014/236842 Text en Copyright © 2014 Fulvia Ceccarelli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Ceccarelli, Fulvia Perricone, Carlo Massaro, Laura Pacucci, Viviana Antonella Cipriano, Enrica Truglia, Simona Miranda, Francesca Spinelli, Francesca Romana Alessandri, Cristiano Valesini, Guido Conti, Fabrizio The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus |
title | The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus |
title_full | The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus |
title_fullStr | The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus |
title_full_unstemmed | The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus |
title_short | The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus |
title_sort | role of disease activity score 28 in the evaluation of articular involvement in systemic lupus erythematosus |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235977/ https://www.ncbi.nlm.nih.gov/pubmed/25530992 http://dx.doi.org/10.1155/2014/236842 |
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