Intestine-Targeted DGAT1 Inhibition Improves Obesity and Insulin Resistance without Skin Aberrations in Mice

OBJECTIVE: Diacylglycerol O-acyltransferase 1 (DGAT1) catalyzes the final committed step in triglyceride biosynthesis. DGAT1 null mice are known to be resistant to diet-induced obesity, and more insulin sensitive relative to the wild-type; however, the mice exhibit abnormalities in the skin. This wo...

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Detalles Bibliográficos
Autores principales: Tsuda, Naoto, Kumadaki, Shin, Higashi, Chika, Ozawa, Makoto, Shinozaki, Mikihiko, Kato, Yutaka, Hoshida, Koutarou, Kikuchi, Satomi, Nakano, Yoshihisa, Ogawa, Yoshihiro, Furusako, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236014/
https://www.ncbi.nlm.nih.gov/pubmed/25405858
http://dx.doi.org/10.1371/journal.pone.0112027

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