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The Design and Construction of an Electrohydrodynamic Cartesian Robot for the Preparation of Tissue Engineering Constructs
In this work we bring together replicating rapid prototyping technology with electrohydrodynamic phenomena to develop a device with the ability to build structures in three-dimensions while simultaneously affording the user a degree of designing versatility and ease that is not seen in conventional...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236048/ https://www.ncbi.nlm.nih.gov/pubmed/25405473 http://dx.doi.org/10.1371/journal.pone.0112166 |
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author | Hashimdeen, Shaikh Hafeez Miodownik, Mark Edirisinghe, Mohan J. |
author_facet | Hashimdeen, Shaikh Hafeez Miodownik, Mark Edirisinghe, Mohan J. |
author_sort | Hashimdeen, Shaikh Hafeez |
collection | PubMed |
description | In this work we bring together replicating rapid prototyping technology with electrohydrodynamic phenomena to develop a device with the ability to build structures in three-dimensions while simultaneously affording the user a degree of designing versatility and ease that is not seen in conventional computer numerically controlled machines. An attempt at reproducing an actual human ear using polycaprolactone was pursued to validate the hardware. Five different polycaprolactone solution concentrations between 7–15 wt% were used and printing was performed at applied voltages that ranged from 1 to 6 kV and at flow rates from 5µl/min to 60µl/min. The corresponding geometrical and aesthetic features of the printed constructs were studied to determine the effectiveness of the device. The 15 wt% concentration at 60µl/min under an applied electric field of 6 kV was identified as the best operating parameters to work with. |
format | Online Article Text |
id | pubmed-4236048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42360482014-11-21 The Design and Construction of an Electrohydrodynamic Cartesian Robot for the Preparation of Tissue Engineering Constructs Hashimdeen, Shaikh Hafeez Miodownik, Mark Edirisinghe, Mohan J. PLoS One Research Article In this work we bring together replicating rapid prototyping technology with electrohydrodynamic phenomena to develop a device with the ability to build structures in three-dimensions while simultaneously affording the user a degree of designing versatility and ease that is not seen in conventional computer numerically controlled machines. An attempt at reproducing an actual human ear using polycaprolactone was pursued to validate the hardware. Five different polycaprolactone solution concentrations between 7–15 wt% were used and printing was performed at applied voltages that ranged from 1 to 6 kV and at flow rates from 5µl/min to 60µl/min. The corresponding geometrical and aesthetic features of the printed constructs were studied to determine the effectiveness of the device. The 15 wt% concentration at 60µl/min under an applied electric field of 6 kV was identified as the best operating parameters to work with. Public Library of Science 2014-11-18 /pmc/articles/PMC4236048/ /pubmed/25405473 http://dx.doi.org/10.1371/journal.pone.0112166 Text en © 2014 Hashimdeen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hashimdeen, Shaikh Hafeez Miodownik, Mark Edirisinghe, Mohan J. The Design and Construction of an Electrohydrodynamic Cartesian Robot for the Preparation of Tissue Engineering Constructs |
title | The Design and Construction of an Electrohydrodynamic Cartesian Robot for the Preparation of Tissue Engineering Constructs |
title_full | The Design and Construction of an Electrohydrodynamic Cartesian Robot for the Preparation of Tissue Engineering Constructs |
title_fullStr | The Design and Construction of an Electrohydrodynamic Cartesian Robot for the Preparation of Tissue Engineering Constructs |
title_full_unstemmed | The Design and Construction of an Electrohydrodynamic Cartesian Robot for the Preparation of Tissue Engineering Constructs |
title_short | The Design and Construction of an Electrohydrodynamic Cartesian Robot for the Preparation of Tissue Engineering Constructs |
title_sort | design and construction of an electrohydrodynamic cartesian robot for the preparation of tissue engineering constructs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236048/ https://www.ncbi.nlm.nih.gov/pubmed/25405473 http://dx.doi.org/10.1371/journal.pone.0112166 |
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