Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells

We explored the cytotoxic effects of nanobacteria (NB) and nanohydroxyapatites (nHAPs) against human choriocarcinoma cells (JAR) and the mechanisms of action underlying their cytotoxicity. JAR cells were co-cultured with NB and nHAPs for 48 h, and ultrastructural changes were more readily induced by...

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Autores principales: Zhang, Mingjun, Yang, Jinmei, Shu, Jing, Fu, Changhong, Liu, Shengnan, Xu, Ge, Zhang, Dechun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236216/
https://www.ncbi.nlm.nih.gov/pubmed/25411570
http://dx.doi.org/10.1186/1556-276X-9-616
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author Zhang, Mingjun
Yang, Jinmei
Shu, Jing
Fu, Changhong
Liu, Shengnan
Xu, Ge
Zhang, Dechun
author_facet Zhang, Mingjun
Yang, Jinmei
Shu, Jing
Fu, Changhong
Liu, Shengnan
Xu, Ge
Zhang, Dechun
author_sort Zhang, Mingjun
collection PubMed
description We explored the cytotoxic effects of nanobacteria (NB) and nanohydroxyapatites (nHAPs) against human choriocarcinoma cells (JAR) and the mechanisms of action underlying their cytotoxicity. JAR cells were co-cultured with NB and nHAPs for 48 h, and ultrastructural changes were more readily induced by NB than nHAPs. Autophagy in the plasma of JAR cells were observed in the NB group. The rate of apoptosis induced by NB was higher than that for nHAPs. The expression of Bax and FasR proteins in the NB group was stronger than that for the nHAP group. NB probably resulted in autophagic formation. Apoptosis was possibly activated via FasL binding to the FasR signaling pathway.
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spelling pubmed-42362162014-11-19 Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells Zhang, Mingjun Yang, Jinmei Shu, Jing Fu, Changhong Liu, Shengnan Xu, Ge Zhang, Dechun Nanoscale Res Lett Nano Express We explored the cytotoxic effects of nanobacteria (NB) and nanohydroxyapatites (nHAPs) against human choriocarcinoma cells (JAR) and the mechanisms of action underlying their cytotoxicity. JAR cells were co-cultured with NB and nHAPs for 48 h, and ultrastructural changes were more readily induced by NB than nHAPs. Autophagy in the plasma of JAR cells were observed in the NB group. The rate of apoptosis induced by NB was higher than that for nHAPs. The expression of Bax and FasR proteins in the NB group was stronger than that for the nHAP group. NB probably resulted in autophagic formation. Apoptosis was possibly activated via FasL binding to the FasR signaling pathway. Springer 2014-11-14 /pmc/articles/PMC4236216/ /pubmed/25411570 http://dx.doi.org/10.1186/1556-276X-9-616 Text en Copyright © 2014 Zhang et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Nano Express
Zhang, Mingjun
Yang, Jinmei
Shu, Jing
Fu, Changhong
Liu, Shengnan
Xu, Ge
Zhang, Dechun
Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells
title Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells
title_full Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells
title_fullStr Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells
title_full_unstemmed Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells
title_short Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells
title_sort cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236216/
https://www.ncbi.nlm.nih.gov/pubmed/25411570
http://dx.doi.org/10.1186/1556-276X-9-616
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