Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

BACKGROUND: MUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research. As one of its splice variants, MUC4/Y with coding sequence is most similar to that of the full-length MUC4 (FL-MU...

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Detalles Bibliográficos
Autores principales: Zhu, Yi, Zhang, Jing-Jing, Xie, Kun-Ling, Tang, Jie, Liang, Wen-Biao, Zhu, Rong, Zhu, Yan, Wang, Bin, Tao, Jin-Qiu, Zhi, Xiao-Fei, Li, Zheng, Gao, Wen-Tao, Jiang, Kui-Rong, Miao, Yi, Xu, Ze-Kuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236435/
https://www.ncbi.nlm.nih.gov/pubmed/25367394
http://dx.doi.org/10.1186/s12967-014-0309-8

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