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Motor features in posterior cortical atrophy and their imaging correlates()
Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by impaired higher visual processing skills; however, motor features more commonly associated with corticobasal syndrome may also occur. We investigated the frequency and clinical characteristics of motor features in 44 P...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236588/ https://www.ncbi.nlm.nih.gov/pubmed/25086839 http://dx.doi.org/10.1016/j.neurobiolaging.2014.05.028 |
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author | Ryan, Natalie S. Shakespeare, Timothy J. Lehmann, Manja Keihaninejad, Shiva Nicholas, Jennifer M. Leung, Kelvin K. Fox, Nick C. Crutch, Sebastian J. |
author_facet | Ryan, Natalie S. Shakespeare, Timothy J. Lehmann, Manja Keihaninejad, Shiva Nicholas, Jennifer M. Leung, Kelvin K. Fox, Nick C. Crutch, Sebastian J. |
author_sort | Ryan, Natalie S. |
collection | PubMed |
description | Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by impaired higher visual processing skills; however, motor features more commonly associated with corticobasal syndrome may also occur. We investigated the frequency and clinical characteristics of motor features in 44 PCA patients and, with 30 controls, conducted voxel-based morphometry, cortical thickness, and subcortical volumetric analyses of their magnetic resonance imaging. Prominent limb rigidity was used to define a PCA-motor subgroup. A total of 30% (13) had PCA-motor; all demonstrating asymmetrical left upper limb rigidity. Limb apraxia was more frequent and asymmetrical in PCA-motor, as was myoclonus. Tremor and alien limb phenomena only occurred in this subgroup. The subgroups did not differ in neuropsychological test performance or apolipoprotein E4 allele frequency. Greater asymmetry of atrophy occurred in PCA-motor, particularly involving right frontoparietal and peri-rolandic cortices, putamen, and thalamus. The 9 patients (including 4 PCA-motor) with pathology or cerebrospinal fluid all showed evidence of Alzheimer's disease. Our data suggest that PCA patients with motor features have greater atrophy of contralateral sensorimotor areas but are still likely to have underlying Alzheimer's disease. |
format | Online Article Text |
id | pubmed-4236588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-42365882014-12-01 Motor features in posterior cortical atrophy and their imaging correlates() Ryan, Natalie S. Shakespeare, Timothy J. Lehmann, Manja Keihaninejad, Shiva Nicholas, Jennifer M. Leung, Kelvin K. Fox, Nick C. Crutch, Sebastian J. Neurobiol Aging Regular Article Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by impaired higher visual processing skills; however, motor features more commonly associated with corticobasal syndrome may also occur. We investigated the frequency and clinical characteristics of motor features in 44 PCA patients and, with 30 controls, conducted voxel-based morphometry, cortical thickness, and subcortical volumetric analyses of their magnetic resonance imaging. Prominent limb rigidity was used to define a PCA-motor subgroup. A total of 30% (13) had PCA-motor; all demonstrating asymmetrical left upper limb rigidity. Limb apraxia was more frequent and asymmetrical in PCA-motor, as was myoclonus. Tremor and alien limb phenomena only occurred in this subgroup. The subgroups did not differ in neuropsychological test performance or apolipoprotein E4 allele frequency. Greater asymmetry of atrophy occurred in PCA-motor, particularly involving right frontoparietal and peri-rolandic cortices, putamen, and thalamus. The 9 patients (including 4 PCA-motor) with pathology or cerebrospinal fluid all showed evidence of Alzheimer's disease. Our data suggest that PCA patients with motor features have greater atrophy of contralateral sensorimotor areas but are still likely to have underlying Alzheimer's disease. Elsevier 2014-12 /pmc/articles/PMC4236588/ /pubmed/25086839 http://dx.doi.org/10.1016/j.neurobiolaging.2014.05.028 Text en © 2014 The Authors https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) . |
spellingShingle | Regular Article Ryan, Natalie S. Shakespeare, Timothy J. Lehmann, Manja Keihaninejad, Shiva Nicholas, Jennifer M. Leung, Kelvin K. Fox, Nick C. Crutch, Sebastian J. Motor features in posterior cortical atrophy and their imaging correlates() |
title | Motor features in posterior cortical atrophy and their imaging correlates() |
title_full | Motor features in posterior cortical atrophy and their imaging correlates() |
title_fullStr | Motor features in posterior cortical atrophy and their imaging correlates() |
title_full_unstemmed | Motor features in posterior cortical atrophy and their imaging correlates() |
title_short | Motor features in posterior cortical atrophy and their imaging correlates() |
title_sort | motor features in posterior cortical atrophy and their imaging correlates() |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236588/ https://www.ncbi.nlm.nih.gov/pubmed/25086839 http://dx.doi.org/10.1016/j.neurobiolaging.2014.05.028 |
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