Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models

PURPOSE: The aim of the study was to demonstrate the activity of etirinotecan pegol, a polymer conjugate of irinotecan, in multiple human tumor models and to establish both the pharmacokinetic/pharmacodynamics (PK/PD) relationship and clinical relevance of the findings. EXPERIMENTAL DESIGN: Anti-tum...

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Detalles Bibliográficos
Autores principales: Hoch, Ute, Staschen, Carl-Michael, Johnson, Randall K., Eldon, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236622/
https://www.ncbi.nlm.nih.gov/pubmed/25228368
http://dx.doi.org/10.1007/s00280-014-2577-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236622/
https://www.ncbi.nlm.nih.gov/pubmed/25228368
http://dx.doi.org/10.1007/s00280-014-2577-7

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