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Acute interstitial nephritis induced by Dioscorea quinqueloba

BACKGROUND: The use of herbal medicine may be a risk factor for the development of kidney injury, as it has been reported to cause various renal syndromes. Dioscorea quinqueloba is a medicinal herb that is used as an alternative therapy for cardiovascular disease and various medical conditions. CASE...

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Autores principales: Kim, Ha Yeon, Kim, Sung Sun, Bae, Soo Hyeon, Bae, Eun Hui, Ma, Seong Kwon, Kim, Soo Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236634/
https://www.ncbi.nlm.nih.gov/pubmed/25186588
http://dx.doi.org/10.1186/1471-2369-15-143
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author Kim, Ha Yeon
Kim, Sung Sun
Bae, Soo Hyeon
Bae, Eun Hui
Ma, Seong Kwon
Kim, Soo Wan
author_facet Kim, Ha Yeon
Kim, Sung Sun
Bae, Soo Hyeon
Bae, Eun Hui
Ma, Seong Kwon
Kim, Soo Wan
author_sort Kim, Ha Yeon
collection PubMed
description BACKGROUND: The use of herbal medicine may be a risk factor for the development of kidney injury, as it has been reported to cause various renal syndromes. Dioscorea quinqueloba is a medicinal herb that is used as an alternative therapy for cardiovascular disease and various medical conditions. CASE PRESENTATION: A 52-year-old man was admitted with complaints of skin rash and burning sensation. He had ingested a raw extract of D. quinqueloba as a traditional remedy. Laboratory tests revealed the following values: absolute eosinophil count, 900/mm(3); serum creatinine level, 2.7 mg/dL; and blood urea nitrogen, 33.0 mg/dL. The immunoglobulin E level was markedly increased at 1320.0 IU/mL. Urinalysis revealed a fractional excretion of sodium of 3.77%, protein 1+, and blood 3+. Histological examination of the renal biopsy specimen showed a diffusely edematous interstitium with infiltrates composed of eosinophils, lymphocytes, and neutrophils. CONCLUSION: Here, we present the first reported case of biopsy-proven acute interstitial nephritis following ingestion of D. quinqueloba associated with skin rash, eosinophilia, and increased plasma immunoglobulin E level.
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spelling pubmed-42366342014-11-19 Acute interstitial nephritis induced by Dioscorea quinqueloba Kim, Ha Yeon Kim, Sung Sun Bae, Soo Hyeon Bae, Eun Hui Ma, Seong Kwon Kim, Soo Wan BMC Nephrol Case Report BACKGROUND: The use of herbal medicine may be a risk factor for the development of kidney injury, as it has been reported to cause various renal syndromes. Dioscorea quinqueloba is a medicinal herb that is used as an alternative therapy for cardiovascular disease and various medical conditions. CASE PRESENTATION: A 52-year-old man was admitted with complaints of skin rash and burning sensation. He had ingested a raw extract of D. quinqueloba as a traditional remedy. Laboratory tests revealed the following values: absolute eosinophil count, 900/mm(3); serum creatinine level, 2.7 mg/dL; and blood urea nitrogen, 33.0 mg/dL. The immunoglobulin E level was markedly increased at 1320.0 IU/mL. Urinalysis revealed a fractional excretion of sodium of 3.77%, protein 1+, and blood 3+. Histological examination of the renal biopsy specimen showed a diffusely edematous interstitium with infiltrates composed of eosinophils, lymphocytes, and neutrophils. CONCLUSION: Here, we present the first reported case of biopsy-proven acute interstitial nephritis following ingestion of D. quinqueloba associated with skin rash, eosinophilia, and increased plasma immunoglobulin E level. BioMed Central 2014-09-03 /pmc/articles/PMC4236634/ /pubmed/25186588 http://dx.doi.org/10.1186/1471-2369-15-143 Text en Copyright © 2014 Kim et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kim, Ha Yeon
Kim, Sung Sun
Bae, Soo Hyeon
Bae, Eun Hui
Ma, Seong Kwon
Kim, Soo Wan
Acute interstitial nephritis induced by Dioscorea quinqueloba
title Acute interstitial nephritis induced by Dioscorea quinqueloba
title_full Acute interstitial nephritis induced by Dioscorea quinqueloba
title_fullStr Acute interstitial nephritis induced by Dioscorea quinqueloba
title_full_unstemmed Acute interstitial nephritis induced by Dioscorea quinqueloba
title_short Acute interstitial nephritis induced by Dioscorea quinqueloba
title_sort acute interstitial nephritis induced by dioscorea quinqueloba
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236634/
https://www.ncbi.nlm.nih.gov/pubmed/25186588
http://dx.doi.org/10.1186/1471-2369-15-143
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