Cargando…

Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer’s disease

BACKGROUND: High-profile Phase 3 clinical trials of bapineuzumab and solanezumab, antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. Neither drug improves clinical outcomes in patients with late onset AD, joining a long list of unsuccessful attempts to tre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castello, Michael A, Jeppson, John David, Soriano, Salvador
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Debate
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236650/ https://www.ncbi.nlm.nih.gov/pubmed/25179671 http://dx.doi.org/10.1186/s12883-014-0169-0

Ejemplares similares

Moving beyond Aim Three: a need for a transdisciplinary approach to build capacity for economic evaluations in implementation science
por: Barnett, Miya L., et al.
Publicado: (2021)

Is pathological aging a successful resistance against amyloid-beta or preclinical Alzheimer’s disease?
por: Murray, Melissa E, et al.
Publicado: (2014)

Antimicrobial resistance – moving forward?
por: Lomazzi, Marta, et al.
Publicado: (2019)

‘Treatment resistance’ in electroconvulsive therapy (ECT) patients: time to move on
por: Kellner, C. H., et al.
Publicado: (2019)

Improving lung cancer survival; time to move on
por: Heuvers, Marlies E, et al.
Publicado: (2012)

Should interventions to treat or prevent Alzheimer’s disease be tested in a population or as targeted treatment of highly selected study participants?
por: Ousset, Pierre Jean, et al.
Publicado: (2013)

Precision public health to inhibit the contagion of disease and move toward a future in which microbes spread health
por: Thaler, David S., et al.
Publicado: (2019)

Pro: Are we ready to translate Alzheimer's disease modifying therapies to people with Down syndrome?
por: Rafii, Michael S
Publicado: (2014)

Modernising the regulation of medical migration: moving from national monopolies to international markets
por: Epstein, Richard J, et al.
Publicado: (2012)

Give PrEP a chance: moving on from the “risk compensation” concept
por: Rojas Castro, Daniela, et al.
Publicado: (2019)

Peering beyond the walls of healthcare institutions: a catalyst for innovation
por: Elrod, James K., et al.
Publicado: (2017)

Con: are we ready to translate Alzheimer’s disease-modifying therapies to people with down syndrome?
por: Head, Elizabeth, et al.
Publicado: (2014)

Moving from ideas to action - developing health financing systems towards universal coverage in Africa
por: Musango, Laurent, et al.
Publicado: (2012)

Financing the Millennium Development Goals for health and beyond: sustaining the 'Big Push'
por: Ooms, Gorik, et al.
Publicado: (2010)

Randomised controlled trials and clinical maternity care: moving on from intention-to-treat and other simplistic analyses of efficacy
por: AW, Welsh
Publicado: (2013)

Cosmopolitanism and foreign policy for health: ethics for and beyond the state
por: Lencucha, Raphael
Publicado: (2013)

The path toward ectogenesis: looking beyond the technical challenges
por: Segers, Seppe
Publicado: (2021)

Preoperative management of antiplatelet drugs for a coronary artery stent: how can we hit a moving target?
por: Vetter, Thomas R, et al.
Publicado: (2014)

A strategy for reducing maternal and newborn deaths by 2015 and beyond
por: Darmstadt, Gary L, et al.
Publicado: (2013)

Beyond mapping: a case for geospatial analytics in humanitarian health
por: Greenough, P. Gregg, et al.
Publicado: (2019)

The growing caseload of chronic life-long conditions calls for a move towards full self-management in low-income countries
por: van Olmen, Josefien, et al.
Publicado: (2011)

Implementation of isoniazid preventive therapy in people living with HIV in Zambia: challenges and lessons
por: Kagujje, Mary, et al.
Publicado: (2019)

Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme
por: Verhoeff, Joost JC, et al.
Publicado: (2009)

Is the risk of Alzheimer’s disease and dementia declining?
por: Langa, Kenneth M
Publicado: (2015)

Prepared for what? addressing the disaster readiness gap beyond preparedness for survival
por: Gowan, Monica E., et al.
Publicado: (2015)

Moving towards a more inclusive patient and public involvement in health research paradigm: the incorporation of a trauma-informed intersectional analysis
por: Shimmin, Carolyn, et al.
Publicado: (2017)

Research on the pathophysiology, treatment, and prevention of suicide: practical and ethical issues
por: Nugent, Allison C., et al.
Publicado: (2019)

The physician's unique role in preventing violence: a neglected opportunity?
por: Umhau, John C, et al.
Publicado: (2012)

Declaration on mental health in Africa: moving to implementation
por: Daar, Abdallah S., et al.
Publicado: (2014)

Beyond crystal balls: crosscutting solutions in global health to prepare for an unpredictable future
por: Alonso, Wladimir Jimenez, et al.
Publicado: (2015)

Beyond surgery: clinical and economic impact of Enhanced Recovery After Surgery programs
por: Joliat, Gaëtan-Romain, et al.
Publicado: (2018)

Beyond artificial academic debates: for a diverse, inclusive, and impactful ethnobiology and ethnomedicine
por: Reyes-García, Victoria
Publicado: (2023)

Heterogeneity of Alzheimer’s disease: consequence for drug trials?
por: Devi, Gayatri, et al.
Publicado: (2018)

Beyond “implementation strategies”: classifying the full range of strategies used in implementation science and practice
por: Leeman, Jennifer, et al.
Publicado: (2017)

Pro: Alzheimer's disease and circadian dysfunction: chicken or egg?
por: Bedrosian, Tracy A, et al.
Publicado: (2012)

Con: Alzheimer's disease and circadian dysfunction: chicken or egg?
por: Moghekar, Abhay, et al.
Publicado: (2012)

High adiposity: risk factor for dementia and Alzheimer’s disease?
por: Gustafson, Deborah R, et al.
Publicado: (2013)

Lessons from obesity prevention for the prevention of mental disorders: the primordial prevention approach
por: Hayward, Joshua, et al.
Publicado: (2014)

Beyond ethical and curricular guidelines in global health: attitudinal development on international service-learning trips
por: Ventres, William B, et al.
Publicado: (2015)

Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority
por: Niedzwiedz, Claire L., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3aoif22u1hhk1dbq4b939194rb