Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors

Hepatitis C virus (HCV) replication is dependent on a liver-specific microRNA (miRNA), miR-122. A recent clinical trial reported that transient inhibition of miR-122 reduced viral titers in HCV infected patients. Here we set out to better understand how miR-122 inhibition influences HCV replication...

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Detalles Bibliográficos
Autores principales: Israelow, Benjamin, Mullokandov, Gavriel, Agudo, Judith, Sourisseau, Marion, Bashir, Ali, Maldonado, Andres Y., Dar, Arvin C., Brown, Brian D., Evans, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236719/
https://www.ncbi.nlm.nih.gov/pubmed/25403145
http://dx.doi.org/10.1038/ncomms6408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236719/
https://www.ncbi.nlm.nih.gov/pubmed/25403145
http://dx.doi.org/10.1038/ncomms6408

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