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Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study
BACKGROUND: Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients. METHODS: To investigate whether the home-based exercise training program can reduce inflammatory biomarkers in patients...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236722/ https://www.ncbi.nlm.nih.gov/pubmed/25175787 http://dx.doi.org/10.1186/1471-2466-14-142 |
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author | Wang, Chun-Hua Chou, Pai-Chien Joa, Wen-Ching Chen, Li-Fei Sheng, Te-Fang Ho, Shu-Chuan Lin, Horng-Chyuan Huang, Chien-Da Chung, Fu-Tsai Chung, Kian Fan Kuo, Han-Pin |
author_facet | Wang, Chun-Hua Chou, Pai-Chien Joa, Wen-Ching Chen, Li-Fei Sheng, Te-Fang Ho, Shu-Chuan Lin, Horng-Chyuan Huang, Chien-Da Chung, Fu-Tsai Chung, Kian Fan Kuo, Han-Pin |
author_sort | Wang, Chun-Hua |
collection | PubMed |
description | BACKGROUND: Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients. METHODS: To investigate whether the home-based exercise training program can reduce inflammatory biomarkers in patients with COPD, twelve patients using mobile phone assistance and 14 with free walk were assessed by incremental shuttle walk test (ISWT), spirometry, strength of limb muscles, and serum C-reactive protein (CRP) and inflammatory cytokines. RESULTS: Patients in the mobile phone group improved their ISWT walking distance, with decrease in serum CRP after 2 months, and sustained at 6 months. Patients in the control group had no improvement. Serum IL-8 in the mobile phone group was significantly reduced at 2, 3 and 6 months after doing home exercise training compared to baseline. IL-6 and TNF-α were significantly elevated at 3 and 6 months in control group, while there were no changes in mobile phone group. The strength of limb muscles was significantly greater compared to baseline at 3 and 6 months in the mobile phone group. CONCLUSIONS: A mobile-phone-based system can provide an efficient home endurance exercise training program with improved exercise capacity, strength of limb muscles and a decrease in serum CRP and IL-8 in COPD patients. Decreased systemic inflammation may contribute to these clinical benefits. (Clinical trial registration No.: NCT01631019) |
format | Online Article Text |
id | pubmed-4236722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42367222014-11-20 Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study Wang, Chun-Hua Chou, Pai-Chien Joa, Wen-Ching Chen, Li-Fei Sheng, Te-Fang Ho, Shu-Chuan Lin, Horng-Chyuan Huang, Chien-Da Chung, Fu-Tsai Chung, Kian Fan Kuo, Han-Pin BMC Pulm Med Research Article BACKGROUND: Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients. METHODS: To investigate whether the home-based exercise training program can reduce inflammatory biomarkers in patients with COPD, twelve patients using mobile phone assistance and 14 with free walk were assessed by incremental shuttle walk test (ISWT), spirometry, strength of limb muscles, and serum C-reactive protein (CRP) and inflammatory cytokines. RESULTS: Patients in the mobile phone group improved their ISWT walking distance, with decrease in serum CRP after 2 months, and sustained at 6 months. Patients in the control group had no improvement. Serum IL-8 in the mobile phone group was significantly reduced at 2, 3 and 6 months after doing home exercise training compared to baseline. IL-6 and TNF-α were significantly elevated at 3 and 6 months in control group, while there were no changes in mobile phone group. The strength of limb muscles was significantly greater compared to baseline at 3 and 6 months in the mobile phone group. CONCLUSIONS: A mobile-phone-based system can provide an efficient home endurance exercise training program with improved exercise capacity, strength of limb muscles and a decrease in serum CRP and IL-8 in COPD patients. Decreased systemic inflammation may contribute to these clinical benefits. (Clinical trial registration No.: NCT01631019) BioMed Central 2014-08-30 /pmc/articles/PMC4236722/ /pubmed/25175787 http://dx.doi.org/10.1186/1471-2466-14-142 Text en Copyright © 2014 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wang, Chun-Hua Chou, Pai-Chien Joa, Wen-Ching Chen, Li-Fei Sheng, Te-Fang Ho, Shu-Chuan Lin, Horng-Chyuan Huang, Chien-Da Chung, Fu-Tsai Chung, Kian Fan Kuo, Han-Pin Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study |
title | Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study |
title_full | Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study |
title_fullStr | Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study |
title_full_unstemmed | Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study |
title_short | Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study |
title_sort | mobile-phone-based home exercise training program decreases systemic inflammation in copd: a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236722/ https://www.ncbi.nlm.nih.gov/pubmed/25175787 http://dx.doi.org/10.1186/1471-2466-14-142 |
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