Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3

The centromere-specific histone H3 variant, CENP-A, is overexpressed in particular aggressive cancer cells, where it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. In the present study, we report the crystal structure of the heterotypic CENP-A/H3.3 particle a...

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Detalles Bibliográficos
Autores principales: Arimura, Yasuhiro, Shirayama, Kazuyoshi, Horikoshi, Naoki, Fujita, Risa, Taguchi, Hiroyuki, Kagawa, Wataru, Fukagawa, Tatsuo, Almouzni, Geneviève, Kurumizaka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236741/
https://www.ncbi.nlm.nih.gov/pubmed/25408271
http://dx.doi.org/10.1038/srep07115

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