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Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden

BACKGROUND: Establishment of haematological and biochemical reference intervals is important to assess health of animals on individual and population level. Reference intervals for 13 haematological and 34 biochemical variables were established based on 88 apparently healthy free-ranging brown bears...

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Autores principales: Græsli, Anne Randi, Fahlman, Åsa, Evans, Alina L, Bertelsen, Mads Frost, Arnemo, Jon Martin, Nielsen, Søren Saxmose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236794/
https://www.ncbi.nlm.nih.gov/pubmed/25139149
http://dx.doi.org/10.1186/s12917-014-0183-x
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author Græsli, Anne Randi
Fahlman, Åsa
Evans, Alina L
Bertelsen, Mads Frost
Arnemo, Jon Martin
Nielsen, Søren Saxmose
author_facet Græsli, Anne Randi
Fahlman, Åsa
Evans, Alina L
Bertelsen, Mads Frost
Arnemo, Jon Martin
Nielsen, Søren Saxmose
author_sort Græsli, Anne Randi
collection PubMed
description BACKGROUND: Establishment of haematological and biochemical reference intervals is important to assess health of animals on individual and population level. Reference intervals for 13 haematological and 34 biochemical variables were established based on 88 apparently healthy free-ranging brown bears (39 males and 49 females) in Sweden. The animals were chemically immobilised by darting from a helicopter with a combination of medetomidine, tiletamine and zolazepam in April and May 2006–2012 in the county of Dalarna, Sweden. Venous blood samples were collected during anaesthesia for radio collaring and marking for ecological studies. For each of the variables, the reference interval was described based on the 95% confidence interval, and differences due to host characteristics sex and age were included if detected. To our knowledge, this is the first report of reference intervals for free-ranging brown bears in Sweden. RESULTS: The following variables were not affected by host characteristics: red blood cell, white blood cell, monocyte and platelet count, alanine transaminase, amylase, bilirubin, free fatty acids, glucose, calcium, chloride, potassium, and cortisol. Age differences were seen for the majority of the haematological variables, whereas sex influenced only mean corpuscular haemoglobin concentration, aspartate aminotransferase, lipase, lactate dehydrogenase, β-globulin, bile acids, triglycerides and sodium. CONCLUSIONS: The biochemical and haematological reference intervals provided and the differences due to host factors age and gender can be useful for evaluation of health status in free-ranging European brown bears.
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spelling pubmed-42367942014-11-24 Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden Græsli, Anne Randi Fahlman, Åsa Evans, Alina L Bertelsen, Mads Frost Arnemo, Jon Martin Nielsen, Søren Saxmose BMC Vet Res Research Article BACKGROUND: Establishment of haematological and biochemical reference intervals is important to assess health of animals on individual and population level. Reference intervals for 13 haematological and 34 biochemical variables were established based on 88 apparently healthy free-ranging brown bears (39 males and 49 females) in Sweden. The animals were chemically immobilised by darting from a helicopter with a combination of medetomidine, tiletamine and zolazepam in April and May 2006–2012 in the county of Dalarna, Sweden. Venous blood samples were collected during anaesthesia for radio collaring and marking for ecological studies. For each of the variables, the reference interval was described based on the 95% confidence interval, and differences due to host characteristics sex and age were included if detected. To our knowledge, this is the first report of reference intervals for free-ranging brown bears in Sweden. RESULTS: The following variables were not affected by host characteristics: red blood cell, white blood cell, monocyte and platelet count, alanine transaminase, amylase, bilirubin, free fatty acids, glucose, calcium, chloride, potassium, and cortisol. Age differences were seen for the majority of the haematological variables, whereas sex influenced only mean corpuscular haemoglobin concentration, aspartate aminotransferase, lipase, lactate dehydrogenase, β-globulin, bile acids, triglycerides and sodium. CONCLUSIONS: The biochemical and haematological reference intervals provided and the differences due to host factors age and gender can be useful for evaluation of health status in free-ranging European brown bears. BioMed Central 2014-08-21 /pmc/articles/PMC4236794/ /pubmed/25139149 http://dx.doi.org/10.1186/s12917-014-0183-x Text en Copyright © 2014 Græsli et al.; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Græsli, Anne Randi
Fahlman, Åsa
Evans, Alina L
Bertelsen, Mads Frost
Arnemo, Jon Martin
Nielsen, Søren Saxmose
Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden
title Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden
title_full Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden
title_fullStr Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden
title_full_unstemmed Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden
title_short Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden
title_sort haematological and biochemical reference intervals for free-ranging brown bears (ursus arctos) in sweden
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236794/
https://www.ncbi.nlm.nih.gov/pubmed/25139149
http://dx.doi.org/10.1186/s12917-014-0183-x
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