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Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement

Recently, using the frog Xenopus laevis as a model system, we showed that the transcription factor Rfx2 coordinates many genes involved in ciliogenesis and cell movement in multiciliated cells (Chung et al., 2014). To our knowledge, it was the first paper to utilize the genomic resources, including...

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Detalles Bibliográficos
Autores principales: Kwon, Taejoon, Chung, Mei-I, Gupta, Rakhi, Baker, Julie C., Wallingford, John B., Marcotte, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236849/
https://www.ncbi.nlm.nih.gov/pubmed/25419512
http://dx.doi.org/10.1016/j.gdata.2014.06.015
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author Kwon, Taejoon
Chung, Mei-I
Gupta, Rakhi
Baker, Julie C.
Wallingford, John B.
Marcotte, Edward M.
author_facet Kwon, Taejoon
Chung, Mei-I
Gupta, Rakhi
Baker, Julie C.
Wallingford, John B.
Marcotte, Edward M.
author_sort Kwon, Taejoon
collection PubMed
description Recently, using the frog Xenopus laevis as a model system, we showed that the transcription factor Rfx2 coordinates many genes involved in ciliogenesis and cell movement in multiciliated cells (Chung et al., 2014). To our knowledge, it was the first paper to utilize the genomic resources, including genome sequences and interim gene annotations, from the ongoing X. laevis genome project. For researchers who are interested in the application of genomics and systems biology approaches in Xenopus studies, here we provide additional details about our dataset (NCBI GEO accession number GSE50593) and describe how we analyzed RNA-seq and ChIP-seq data to identify direct targets of Rfx2.
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spelling pubmed-42368492015-10-19 Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement Kwon, Taejoon Chung, Mei-I Gupta, Rakhi Baker, Julie C. Wallingford, John B. Marcotte, Edward M. Genom Data Data in Brief Recently, using the frog Xenopus laevis as a model system, we showed that the transcription factor Rfx2 coordinates many genes involved in ciliogenesis and cell movement in multiciliated cells (Chung et al., 2014). To our knowledge, it was the first paper to utilize the genomic resources, including genome sequences and interim gene annotations, from the ongoing X. laevis genome project. For researchers who are interested in the application of genomics and systems biology approaches in Xenopus studies, here we provide additional details about our dataset (NCBI GEO accession number GSE50593) and describe how we analyzed RNA-seq and ChIP-seq data to identify direct targets of Rfx2. Elsevier 2014-06-26 /pmc/articles/PMC4236849/ /pubmed/25419512 http://dx.doi.org/10.1016/j.gdata.2014.06.015 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Data in Brief
Kwon, Taejoon
Chung, Mei-I
Gupta, Rakhi
Baker, Julie C.
Wallingford, John B.
Marcotte, Edward M.
Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement
title Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement
title_full Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement
title_fullStr Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement
title_full_unstemmed Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement
title_short Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement
title_sort identifying direct targets of transcription factor rfx2 that coordinate ciliogenesis and cell movement
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236849/
https://www.ncbi.nlm.nih.gov/pubmed/25419512
http://dx.doi.org/10.1016/j.gdata.2014.06.015
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