Cargando…

Expression of TNF-α, April and BCMA in Behcet's Disease

Background. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet's disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis fa...

Descripción completa

Detalles Bibliográficos
Autores principales: Shaker, Olfat G., Tawfic, Shereen O., El-Tawdy, Amira M., El-Komy, Mohamed H. M., El Menyawi, Manal, Heikal, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236893/
https://www.ncbi.nlm.nih.gov/pubmed/25759827
http://dx.doi.org/10.1155/2014/380405
_version_ 1782345255528431616
author Shaker, Olfat G.
Tawfic, Shereen O.
El-Tawdy, Amira M.
El-Komy, Mohamed H. M.
El Menyawi, Manal
Heikal, Ahmed A.
author_facet Shaker, Olfat G.
Tawfic, Shereen O.
El-Tawdy, Amira M.
El-Komy, Mohamed H. M.
El Menyawi, Manal
Heikal, Ahmed A.
author_sort Shaker, Olfat G.
collection PubMed
description Background. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet's disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activator and calcium modulator ligand interactor (TACI), and B cell maturation antigen (BCMA) that are expressed by B cells. Objective. Estimation of the serum levels of TNF-α, APRIL, BAFF, and BCMA in patients with BD in an effort to evaluate their degree of involvement in the pathogenesis and development of BD. Patients and Methods. This study included 30 male patients fulfilling the international study group criteria for the diagnosis of BD. Twenty age-matched healthy male volunteers served as control. Serum samples were used for quantification of TNF-α, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques. Results. The mean serum levels of TNF-α, APRIL, BCMA, and BAFF were more elevated in cases than in controls in a statistically significant manner (P < 0.001). Positive correlation was observed between hs-CRP and BDCAF (Behcet's disease current activity forum) index (r 0.68, P < 0.001). None of the TNF family members tested was affected by a positive pathergy test. Conclusions. Patients have significantly higher levels of TNF family members' (TNF-α, BAFF, APRIL, and BCMA) compared to controls which might contribute to the pathogenesis of BD.
format Online
Article
Text
id pubmed-4236893
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-42368932015-03-10 Expression of TNF-α, April and BCMA in Behcet's Disease Shaker, Olfat G. Tawfic, Shereen O. El-Tawdy, Amira M. El-Komy, Mohamed H. M. El Menyawi, Manal Heikal, Ahmed A. J Immunol Res Research Article Background. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet's disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activator and calcium modulator ligand interactor (TACI), and B cell maturation antigen (BCMA) that are expressed by B cells. Objective. Estimation of the serum levels of TNF-α, APRIL, BAFF, and BCMA in patients with BD in an effort to evaluate their degree of involvement in the pathogenesis and development of BD. Patients and Methods. This study included 30 male patients fulfilling the international study group criteria for the diagnosis of BD. Twenty age-matched healthy male volunteers served as control. Serum samples were used for quantification of TNF-α, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques. Results. The mean serum levels of TNF-α, APRIL, BCMA, and BAFF were more elevated in cases than in controls in a statistically significant manner (P < 0.001). Positive correlation was observed between hs-CRP and BDCAF (Behcet's disease current activity forum) index (r 0.68, P < 0.001). None of the TNF family members tested was affected by a positive pathergy test. Conclusions. Patients have significantly higher levels of TNF family members' (TNF-α, BAFF, APRIL, and BCMA) compared to controls which might contribute to the pathogenesis of BD. Hindawi Publishing Corporation 2014 2014-11-05 /pmc/articles/PMC4236893/ /pubmed/25759827 http://dx.doi.org/10.1155/2014/380405 Text en Copyright © 2014 Olfat G. Shaker et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shaker, Olfat G.
Tawfic, Shereen O.
El-Tawdy, Amira M.
El-Komy, Mohamed H. M.
El Menyawi, Manal
Heikal, Ahmed A.
Expression of TNF-α, April and BCMA in Behcet's Disease
title Expression of TNF-α, April and BCMA in Behcet's Disease
title_full Expression of TNF-α, April and BCMA in Behcet's Disease
title_fullStr Expression of TNF-α, April and BCMA in Behcet's Disease
title_full_unstemmed Expression of TNF-α, April and BCMA in Behcet's Disease
title_short Expression of TNF-α, April and BCMA in Behcet's Disease
title_sort expression of tnf-α, april and bcma in behcet's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236893/
https://www.ncbi.nlm.nih.gov/pubmed/25759827
http://dx.doi.org/10.1155/2014/380405
work_keys_str_mv AT shakerolfatg expressionoftnfaaprilandbcmainbehcetsdisease
AT tawficshereeno expressionoftnfaaprilandbcmainbehcetsdisease
AT eltawdyamiram expressionoftnfaaprilandbcmainbehcetsdisease
AT elkomymohamedhm expressionoftnfaaprilandbcmainbehcetsdisease
AT elmenyawimanal expressionoftnfaaprilandbcmainbehcetsdisease
AT heikalahmeda expressionoftnfaaprilandbcmainbehcetsdisease