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EV71 vaccine, an invaluable gift for children
Enterovirus 71 (EV71) is a major pathogen for severe hand, foot and mouth disease (HFMD). Development of vaccines against EV71 would be the most effective approach to prevent the EV71 outbreak. Research and development (R&D) of EV71 vaccine was carried out in several Asian countries. Currently t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237031/ https://www.ncbi.nlm.nih.gov/pubmed/25505956 http://dx.doi.org/10.1038/cti.2014.24 |
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author | Liang, Zhenglun Wang, Junzhi |
author_facet | Liang, Zhenglun Wang, Junzhi |
author_sort | Liang, Zhenglun |
collection | PubMed |
description | Enterovirus 71 (EV71) is a major pathogen for severe hand, foot and mouth disease (HFMD). Development of vaccines against EV71 would be the most effective approach to prevent the EV71 outbreak. Research and development (R&D) of EV71 vaccine was carried out in several Asian countries. Currently three companies in mainland China have completed Phase III clinical trials of inactivated EV71 whole-virus vaccines, whereas the other two companies have completed Phase I clinical trials separately in Taiwan and in Singapore. Results from those clinical trials have indicated high safety and immunogenicity of EV71 vaccine. Protective efficacies were over 90% on EV71-associated HFMD and over 80% on other EV71-associated diseases. In this paper, we summarize the results from three EV71 vaccine Phase III clinical trials and discuss the challenges of incorporating EV71 vaccine into Expanded Program on Immunization (EPI) in countries with EV71 epidemics. |
format | Online Article Text |
id | pubmed-4237031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-42370312014-12-11 EV71 vaccine, an invaluable gift for children Liang, Zhenglun Wang, Junzhi Clin Transl Immunology Review Enterovirus 71 (EV71) is a major pathogen for severe hand, foot and mouth disease (HFMD). Development of vaccines against EV71 would be the most effective approach to prevent the EV71 outbreak. Research and development (R&D) of EV71 vaccine was carried out in several Asian countries. Currently three companies in mainland China have completed Phase III clinical trials of inactivated EV71 whole-virus vaccines, whereas the other two companies have completed Phase I clinical trials separately in Taiwan and in Singapore. Results from those clinical trials have indicated high safety and immunogenicity of EV71 vaccine. Protective efficacies were over 90% on EV71-associated HFMD and over 80% on other EV71-associated diseases. In this paper, we summarize the results from three EV71 vaccine Phase III clinical trials and discuss the challenges of incorporating EV71 vaccine into Expanded Program on Immunization (EPI) in countries with EV71 epidemics. Nature Publishing Group 2014-10-31 /pmc/articles/PMC4237031/ /pubmed/25505956 http://dx.doi.org/10.1038/cti.2014.24 Text en Copyright © 2013 Australasian Society for Immunology Inc. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Review Liang, Zhenglun Wang, Junzhi EV71 vaccine, an invaluable gift for children |
title | EV71 vaccine, an invaluable gift for children |
title_full | EV71 vaccine, an invaluable gift for children |
title_fullStr | EV71 vaccine, an invaluable gift for children |
title_full_unstemmed | EV71 vaccine, an invaluable gift for children |
title_short | EV71 vaccine, an invaluable gift for children |
title_sort | ev71 vaccine, an invaluable gift for children |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237031/ https://www.ncbi.nlm.nih.gov/pubmed/25505956 http://dx.doi.org/10.1038/cti.2014.24 |
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