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Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system

Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here...

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Autores principales: Kitic, Maja, Wimmer, Isabella, Adzemovic, Milena, Kögl, Nikolaus, Rudel, Antonia, Lassmann, Hans, Bradl, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237118/
https://www.ncbi.nlm.nih.gov/pubmed/24668732
http://dx.doi.org/10.1002/glia.22662
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author Kitic, Maja
Wimmer, Isabella
Adzemovic, Milena
Kögl, Nikolaus
Rudel, Antonia
Lassmann, Hans
Bradl, Monika
author_facet Kitic, Maja
Wimmer, Isabella
Adzemovic, Milena
Kögl, Nikolaus
Rudel, Antonia
Lassmann, Hans
Bradl, Monika
author_sort Kitic, Maja
collection PubMed
description Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here that TSLP is also expressed in the central nervous system (CNS) where it is produced by choroid plexus epithelial cells and astrocytes in the spinal cord. Under conditions of low-grade myelin degeneration, the numbers of TSLP-expressing astrocytes increase, and microglia express transcripts for the functional TSLP receptor dimer indicating that these cells are targets for TSLP in the myelin-degenerative CNS.
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spelling pubmed-42371182014-12-15 Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system Kitic, Maja Wimmer, Isabella Adzemovic, Milena Kögl, Nikolaus Rudel, Antonia Lassmann, Hans Bradl, Monika Glia Research Articles Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here that TSLP is also expressed in the central nervous system (CNS) where it is produced by choroid plexus epithelial cells and astrocytes in the spinal cord. Under conditions of low-grade myelin degeneration, the numbers of TSLP-expressing astrocytes increase, and microglia express transcripts for the functional TSLP receptor dimer indicating that these cells are targets for TSLP in the myelin-degenerative CNS. BlackWell Publishing Ltd 2014-07 2014-03-25 /pmc/articles/PMC4237118/ /pubmed/24668732 http://dx.doi.org/10.1002/glia.22662 Text en Copyright © 2014 The Authors. Glia Published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Kitic, Maja
Wimmer, Isabella
Adzemovic, Milena
Kögl, Nikolaus
Rudel, Antonia
Lassmann, Hans
Bradl, Monika
Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system
title Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system
title_full Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system
title_fullStr Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system
title_full_unstemmed Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system
title_short Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system
title_sort thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237118/
https://www.ncbi.nlm.nih.gov/pubmed/24668732
http://dx.doi.org/10.1002/glia.22662
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