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Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system
Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237118/ https://www.ncbi.nlm.nih.gov/pubmed/24668732 http://dx.doi.org/10.1002/glia.22662 |
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author | Kitic, Maja Wimmer, Isabella Adzemovic, Milena Kögl, Nikolaus Rudel, Antonia Lassmann, Hans Bradl, Monika |
author_facet | Kitic, Maja Wimmer, Isabella Adzemovic, Milena Kögl, Nikolaus Rudel, Antonia Lassmann, Hans Bradl, Monika |
author_sort | Kitic, Maja |
collection | PubMed |
description | Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here that TSLP is also expressed in the central nervous system (CNS) where it is produced by choroid plexus epithelial cells and astrocytes in the spinal cord. Under conditions of low-grade myelin degeneration, the numbers of TSLP-expressing astrocytes increase, and microglia express transcripts for the functional TSLP receptor dimer indicating that these cells are targets for TSLP in the myelin-degenerative CNS. |
format | Online Article Text |
id | pubmed-4237118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42371182014-12-15 Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system Kitic, Maja Wimmer, Isabella Adzemovic, Milena Kögl, Nikolaus Rudel, Antonia Lassmann, Hans Bradl, Monika Glia Research Articles Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here that TSLP is also expressed in the central nervous system (CNS) where it is produced by choroid plexus epithelial cells and astrocytes in the spinal cord. Under conditions of low-grade myelin degeneration, the numbers of TSLP-expressing astrocytes increase, and microglia express transcripts for the functional TSLP receptor dimer indicating that these cells are targets for TSLP in the myelin-degenerative CNS. BlackWell Publishing Ltd 2014-07 2014-03-25 /pmc/articles/PMC4237118/ /pubmed/24668732 http://dx.doi.org/10.1002/glia.22662 Text en Copyright © 2014 The Authors. Glia Published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Kitic, Maja Wimmer, Isabella Adzemovic, Milena Kögl, Nikolaus Rudel, Antonia Lassmann, Hans Bradl, Monika Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system |
title | Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system |
title_full | Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system |
title_fullStr | Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system |
title_full_unstemmed | Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system |
title_short | Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system |
title_sort | thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237118/ https://www.ncbi.nlm.nih.gov/pubmed/24668732 http://dx.doi.org/10.1002/glia.22662 |
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