Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone

The search for the elusive Na-K-ATPase-inhibiting natriuretic hormone continues. In this review, evidence is presented that isolating the carrier protein for natriuretic hormone from hypertensive plasma is a necessary first step before splitting off the final hormone. The carrier protein has a molec...

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Detalles Bibliográficos
Autor principal: Gonick, Harvey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237141/
https://www.ncbi.nlm.nih.gov/pubmed/25477863
http://dx.doi.org/10.3389/fendo.2014.00196
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author Gonick, Harvey C.
author_facet Gonick, Harvey C.
author_sort Gonick, Harvey C.
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description The search for the elusive Na-K-ATPase-inhibiting natriuretic hormone continues. In this review, evidence is presented that isolating the carrier protein for natriuretic hormone from hypertensive plasma is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has a molecular weight of 408 Da. Both compounds inhibit Na-K-ATPase but the compound containing the carrier protein predominates. The question has been raised as to whether the carrier protein is in actuality proANF, a 17 kDa protein that can be split between a 14 kDa protein (the presumptive proANF) and the 3 kDa ANF.
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spelling pubmed-42371412014-12-04 Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone Gonick, Harvey C. Front Endocrinol (Lausanne) Endocrinology The search for the elusive Na-K-ATPase-inhibiting natriuretic hormone continues. In this review, evidence is presented that isolating the carrier protein for natriuretic hormone from hypertensive plasma is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has a molecular weight of 408 Da. Both compounds inhibit Na-K-ATPase but the compound containing the carrier protein predominates. The question has been raised as to whether the carrier protein is in actuality proANF, a 17 kDa protein that can be split between a 14 kDa protein (the presumptive proANF) and the 3 kDa ANF. Frontiers Media S.A. 2014-11-19 /pmc/articles/PMC4237141/ /pubmed/25477863 http://dx.doi.org/10.3389/fendo.2014.00196 Text en Copyright © 2014 Gonick. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Gonick, Harvey C.
Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone
title Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone
title_full Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone
title_fullStr Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone
title_full_unstemmed Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone
title_short Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone
title_sort evidence for a 12 kda “carrier protein” for natriuretic hormone
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237141/
https://www.ncbi.nlm.nih.gov/pubmed/25477863
http://dx.doi.org/10.3389/fendo.2014.00196
work_keys_str_mv AT gonickharveyc evidencefora12kdacarrierproteinfornatriuretichormone

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