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Normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in Mexican Tarahumara runners following a 78 km race at moderate altitude

OBJECTIVES: The aim of this study was to examine to what extent extreme endurance exercise results in changes of plasma markers associated with cardiac and renal damage, as well as hemolysis in male, Mexican Tarahumara runners. METHODS: Ten Tarahumara runners (mean (sd) age of 38 (12) years) partici...

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Autores principales: Christensen, Dirk L, Espino, Diana, Infante-Ramírez, Rocío, Brage, Soren, Terzic, Dijana, Goetze, Jens P, Kjaergaard, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237147/
https://www.ncbi.nlm.nih.gov/pubmed/25145663
http://dx.doi.org/10.1002/ajhb.22607
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author Christensen, Dirk L
Espino, Diana
Infante-Ramírez, Rocío
Brage, Soren
Terzic, Dijana
Goetze, Jens P
Kjaergaard, Jesper
author_facet Christensen, Dirk L
Espino, Diana
Infante-Ramírez, Rocío
Brage, Soren
Terzic, Dijana
Goetze, Jens P
Kjaergaard, Jesper
author_sort Christensen, Dirk L
collection PubMed
description OBJECTIVES: The aim of this study was to examine to what extent extreme endurance exercise results in changes of plasma markers associated with cardiac and renal damage, as well as hemolysis in male, Mexican Tarahumara runners. METHODS: Ten Tarahumara runners (mean (sd) age of 38 (12) years) participated in a 78 km race in Chihuahua, Mexico at 2,400 m above sea level. Cardiac, kidney, and hematology plasma markers were measured pre-race and <5 min, 1 h, 3 h, 6 h, 24 h, and 48 h post-race. Anthropometry, blood pressure, pulse rate, electrocardiography, HbA1c, hemoglobin and VO(2max) (estimated from heart rate following step test) were assessed pre-race, while physical activity energy expenditure and intensity were estimated during the race, and oxygen partial pressure saturation (SpO(2)) <30 min post-race. RESULTS: Estimated mean VO(2max) was 48 (9) mLO(2) min(−1) kg(−1) and relative intensity during the race was 68 (11)%VO(2)max. Mean SpO(2) was 92 (3)% <30 min post-race. Plasma concentrations of especially total creatine kinase, creatine kinase-MB isoform, and haptoglobin changed significantly from pre-race values (P < 0.001) up to 24 h post-race, but had returned to pre-race values after 48 h. The plasma concentrations of mid-regional proatrial natiuretic peptide and copeptin returned to pre-race concentrations after 1 and 6 h, respectively. CONCLUSIONS: Altered cardiac, renal, and hemolysis plasma markers were normalized after 48 h following 78 km of running, suggesting that the impact of exercise-induced cardiac and kidney damage as well as hemolysis in the Mexican Tarahumara is low. Am. J. Hum. Biol. 26:836–843, 2014. © 2014 The Authors American Journal of Human Biology Published by Wiley Periodicals, Inc.
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spelling pubmed-42371472014-12-15 Normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in Mexican Tarahumara runners following a 78 km race at moderate altitude Christensen, Dirk L Espino, Diana Infante-Ramírez, Rocío Brage, Soren Terzic, Dijana Goetze, Jens P Kjaergaard, Jesper Am J Hum Biol Original Research Article OBJECTIVES: The aim of this study was to examine to what extent extreme endurance exercise results in changes of plasma markers associated with cardiac and renal damage, as well as hemolysis in male, Mexican Tarahumara runners. METHODS: Ten Tarahumara runners (mean (sd) age of 38 (12) years) participated in a 78 km race in Chihuahua, Mexico at 2,400 m above sea level. Cardiac, kidney, and hematology plasma markers were measured pre-race and <5 min, 1 h, 3 h, 6 h, 24 h, and 48 h post-race. Anthropometry, blood pressure, pulse rate, electrocardiography, HbA1c, hemoglobin and VO(2max) (estimated from heart rate following step test) were assessed pre-race, while physical activity energy expenditure and intensity were estimated during the race, and oxygen partial pressure saturation (SpO(2)) <30 min post-race. RESULTS: Estimated mean VO(2max) was 48 (9) mLO(2) min(−1) kg(−1) and relative intensity during the race was 68 (11)%VO(2)max. Mean SpO(2) was 92 (3)% <30 min post-race. Plasma concentrations of especially total creatine kinase, creatine kinase-MB isoform, and haptoglobin changed significantly from pre-race values (P < 0.001) up to 24 h post-race, but had returned to pre-race values after 48 h. The plasma concentrations of mid-regional proatrial natiuretic peptide and copeptin returned to pre-race concentrations after 1 and 6 h, respectively. CONCLUSIONS: Altered cardiac, renal, and hemolysis plasma markers were normalized after 48 h following 78 km of running, suggesting that the impact of exercise-induced cardiac and kidney damage as well as hemolysis in the Mexican Tarahumara is low. Am. J. Hum. Biol. 26:836–843, 2014. © 2014 The Authors American Journal of Human Biology Published by Wiley Periodicals, Inc. BlackWell Publishing Ltd 2014-11 2014-08-22 /pmc/articles/PMC4237147/ /pubmed/25145663 http://dx.doi.org/10.1002/ajhb.22607 Text en © 2014 Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Christensen, Dirk L
Espino, Diana
Infante-Ramírez, Rocío
Brage, Soren
Terzic, Dijana
Goetze, Jens P
Kjaergaard, Jesper
Normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in Mexican Tarahumara runners following a 78 km race at moderate altitude
title Normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in Mexican Tarahumara runners following a 78 km race at moderate altitude
title_full Normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in Mexican Tarahumara runners following a 78 km race at moderate altitude
title_fullStr Normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in Mexican Tarahumara runners following a 78 km race at moderate altitude
title_full_unstemmed Normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in Mexican Tarahumara runners following a 78 km race at moderate altitude
title_short Normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in Mexican Tarahumara runners following a 78 km race at moderate altitude
title_sort normalization of elevated cardiac, kidney, and hemolysis plasma markers within 48 h in mexican tarahumara runners following a 78 km race at moderate altitude
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237147/
https://www.ncbi.nlm.nih.gov/pubmed/25145663
http://dx.doi.org/10.1002/ajhb.22607
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