HDAC8 and STAT3 repress BMF gene activity in colon cancer cells

Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic...

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Detalles Bibliográficos
Autores principales: Kang, Y, Nian, H, Rajendran, P, Kim, E, Dashwood, W M, Pinto, J T, Boardman, L A, Thibodeau, S N, Limburg, P J, Löhr, C V, Bisson, W H, Williams, D E, Ho, E, Dashwood, R H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237248/
https://www.ncbi.nlm.nih.gov/pubmed/25321483
http://dx.doi.org/10.1038/cddis.2014.422

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