Cargando…

microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells

The molecular mechanisms promoting lineage-specific commitment of human mesenchymal (skeletal or stromal) stem cells (hMSCs) into adipocytes (ADs) are not fully understood. Thus, we performed global microRNA (miRNA) and gene expression profiling during adipocytic differentiation of hMSC, and utilize...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamam, D, Ali, D, Vishnubalaji, R, Hamam, R, Al-Nbaheen, M, Chen, L, Kassem, M, Aldahmash, A, Alajez, N M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237271/ https://www.ncbi.nlm.nih.gov/pubmed/25356868 http://dx.doi.org/10.1038/cddis.2014.462

Ejemplares similares

MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2016)

CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells
por: Al-toub, Mashael, et al.
Publicado: (2015)

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers
por: Hamam, Rimi, et al.
Publicado: (2017)

microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection
por: Hamam, Rimi, et al.
Publicado: (2016)

Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity
por: Ali, Dalia, et al.
Publicado: (2018)

MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2020)

Molecular profiling of ALDH1(+) colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival signalling pathways
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2018)

Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer
por: Vishnubalaji, R, et al.
Publicado: (2015)

Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells
por: Ali, Dalia, et al.
Publicado: (2018)

Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization
por: Elsafadi, M, et al.
Publicado: (2016)

Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2019)

In vitro differentiation of human skin-derived multipotent stromal cells into putative endothelial-like cells
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2012)

Enhanced Efficacy of 5-Fluorouracil in Combination with a Dual Histone Deacetylase and Phosphatidylinositide 3-Kinase Inhibitor (CUDC-907) in Colorectal Cancer Cells
por: Hamam, Rimi, et al.
Publicado: (2017)

Angiogenic Potential of Human Neonatal Foreskin Stromal Cells in the Chick Embryo Chorioallantoic Membrane Model
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2015)

Pleiotropic effects of cancer cells’ secreted factors on human stromal (mesenchymal) stem cells
por: Al-toub, Mashael, et al.
Publicado: (2013)

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
por: AlMuraikhi, Nihal, et al.
Publicado: (2019)

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors
por: Al-toub, Mashael, et al.
Publicado: (2019)

Human Stromal (Mesenchymal) Stem Cells: Basic Biology and Current Clinical Use for Tissue Regeneration
por: Aldahmash, Abdullah, et al.
Publicado: (2012)

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
por: AlMuraikhi, Nihal, et al.
Publicado: (2019)

Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential
por: Al-Nbaheen, May, et al.
Publicado: (2012)

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM
por: Elango, Ramesh, et al.
Publicado: (2020)

Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells
por: AlMuraikhi, Nihal, et al.
Publicado: (2018)

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2016)

Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFβ-dependent manner
por: Elsafadi, Mona, et al.
Publicado: (2020)

Prognostic value of microRNA-125a expression status in molecular groups of pediatric medulloblastoma
por: Hamam, Soheir M., et al.
Publicado: (2023)

MicroRNA-320b Modulates Cholesterol Efflux and Atherosclerosis
por: Lu, Xiaomei, et al.
Publicado: (2022)

Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2021)

Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2021)

Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer Subtypes
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2023)

Long non-coding RNA AC099850.4 correlates with advanced disease state and predicts worse prognosis in triple-negative breast cancer
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2023)

Transplantation of human neonatal foreskin stromal cells in ex vivo organotypic cultures of embryonic chick femurs
por: Aldahmash, Abdullah, et al.
Publicado: (2017)

Transcriptome profiling and network enrichment analyses identify subtype-specific therapeutic gene targets for breast cancer and their microRNA regulatory networks
por: Elango, Ramesh, et al.
Publicado: (2023)

Plasma microRNA-320, microRNA-let-7e and microRNA-21 as novel potential biomarkers for the detection of retinoblastoma
por: LIU, SHAN-SHAN, et al.
Publicado: (2014)

Plasma levels of microRNA-24, microRNA-320a, and microRNA-423-5p are potential biomarkers for colorectal carcinoma
por: Fang, Zanxi, et al.
Publicado: (2015)

MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin
por: Yu, Juan, et al.
Publicado: (2016)

MicroRNA 320, an Anti-Oncogene Target miRNA for Cancer Therapy
por: Liang, Yuanyuan, et al.
Publicado: (2021)

Integrative analysis of microRNA-320a-related genes in osteoarthritis cartilage
por: Peng, Hao, et al.
Publicado: (2023)

Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2020)

LncRNA-Based Classification of Triple Negative Breast Cancer Revealed Inherent Tumor Heterogeneity and Vulnerabilities
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2022)

Whole genome mRNA expression profiling revealed multiple deregulated pathways in stromal vascular fraction from erectile dysfunction patients
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mebqk8uiijgba8bdc4rqduoldi