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Involvement of IKAP in Peripheral Target Innervation and in Specific JNK and NGF Signaling in Developing PNS Neurons

A splicing mutation in the ikbkap gene causes Familial Dysautonomia (FD), affecting the IKAP protein expression levels and proper development and function of the peripheral nervous system (PNS). Here we attempted to elucidate the role of IKAP in PNS development in the chick embryo and found that IKA...

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Detalles Bibliográficos
Autores principales: Abashidze, Anastasia, Gold, Veronica, Anavi, Yaron, Greenspan, Hayit, Weil, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237409/
https://www.ncbi.nlm.nih.gov/pubmed/25409162
http://dx.doi.org/10.1371/journal.pone.0113428