Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2

Myofiber necrosis and fibrosis are hallmarks of Duchenne muscular dystrophy (DMD), leading to lethal weakness of the diaphragm. Macrophages (MPs) are required for successful muscle regeneration, but the role of inflammatory monocyte (MO)-derived MPs in either promoting or mitigating DMD is unclear....

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Detalles Bibliográficos
Autores principales: Mojumdar, Kamalika, Liang, Feng, Giordano, Christian, Lemaire, Christian, Danialou, Gawiyou, Okazaki, Tatsuma, Bourdon, Johanne, Rafei, Moutih, Galipeau, Jacques, Divangahi, Maziar, Petrof, Basil J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237472/
https://www.ncbi.nlm.nih.gov/pubmed/25312642
http://dx.doi.org/10.15252/emmm.201403967

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