Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors

Two new trans-(3R,4R)-amino-β-lactam derivatives and their diastereoisomeric mixtures were synthesized as ezetimibe bioisosteres and tested in in vitro and in vivo experiments as novel β-lactam cholesterol absorption inhibitors. Both compounds exhibited low cytotoxicity in MDCKII, hNPC1L1/MDCKII, an...

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Detalles Bibliográficos
Autores principales: Dražić, Tonko, Molčanov, Krešimir, Sachdev, Vinay, Malnar, Martina, Hećimović, Silva, Patankar, Jay V., Obrowsky, Sascha, Levak-Frank, Sanja, Habuš, Ivan, Kratky, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237514/
https://www.ncbi.nlm.nih.gov/pubmed/25305716
http://dx.doi.org/10.1016/j.ejmech.2014.10.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237514/
https://www.ncbi.nlm.nih.gov/pubmed/25305716
http://dx.doi.org/10.1016/j.ejmech.2014.10.014

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