Nothing but NET: A review of norepinephrine transporter expression and efficacy of (131)I-mIBG therapy

Neuroblastoma is unique amongst common pediatric cancers for its expression of the norepinephrine transporter (NET), enabling tumor-selective imaging and therapy with radioactive analogues of norepinephrine. The majority of neuroblastoma tumors are avid for (123)I-metaiodobenzaguanidine (mIBG) on im...

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Detalles Bibliográficos
Autores principales: Streby, Keri A, Shah, Nilay, Ranalli, Mark A, Kunkler, Anne, Cripe, Timothy P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237663/
https://www.ncbi.nlm.nih.gov/pubmed/25175627
http://dx.doi.org/10.1002/pbc.25200
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author Streby, Keri A
Shah, Nilay
Ranalli, Mark A
Kunkler, Anne
Cripe, Timothy P
author_facet Streby, Keri A
Shah, Nilay
Ranalli, Mark A
Kunkler, Anne
Cripe, Timothy P
author_sort Streby, Keri A
collection PubMed
description Neuroblastoma is unique amongst common pediatric cancers for its expression of the norepinephrine transporter (NET), enabling tumor-selective imaging and therapy with radioactive analogues of norepinephrine. The majority of neuroblastoma tumors are avid for (123)I-metaiodobenzaguanidine (mIBG) on imaging, yet the therapeutic response to (131)I-mIBG is only 30% in clinical trials, and off-target effects cause short- and long-term morbidity. We review the contemporary understanding of the tumor-selective uptake, retention, and efflux of meta-iodobenzylguanidine (mIBG) and strategies currently in development for improving its efficacy. Combination treatment strategies aimed at enhancing NET are likely necessary to reach the full potential of (131)I-mIBG therapy.
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spelling pubmed-42376632015-01-15 Nothing but NET: A review of norepinephrine transporter expression and efficacy of (131)I-mIBG therapy Streby, Keri A Shah, Nilay Ranalli, Mark A Kunkler, Anne Cripe, Timothy P Pediatr Blood Cancer Review Neuroblastoma is unique amongst common pediatric cancers for its expression of the norepinephrine transporter (NET), enabling tumor-selective imaging and therapy with radioactive analogues of norepinephrine. The majority of neuroblastoma tumors are avid for (123)I-metaiodobenzaguanidine (mIBG) on imaging, yet the therapeutic response to (131)I-mIBG is only 30% in clinical trials, and off-target effects cause short- and long-term morbidity. We review the contemporary understanding of the tumor-selective uptake, retention, and efflux of meta-iodobenzylguanidine (mIBG) and strategies currently in development for improving its efficacy. Combination treatment strategies aimed at enhancing NET are likely necessary to reach the full potential of (131)I-mIBG therapy. Wiley Periodicals, Inc 2015-01 2014-08-30 /pmc/articles/PMC4237663/ /pubmed/25175627 http://dx.doi.org/10.1002/pbc.25200 Text en © 2014 The Authors. Pediatric Blood & Cancer Published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Streby, Keri A
Shah, Nilay
Ranalli, Mark A
Kunkler, Anne
Cripe, Timothy P
Nothing but NET: A review of norepinephrine transporter expression and efficacy of (131)I-mIBG therapy
title Nothing but NET: A review of norepinephrine transporter expression and efficacy of (131)I-mIBG therapy
title_full Nothing but NET: A review of norepinephrine transporter expression and efficacy of (131)I-mIBG therapy
title_fullStr Nothing but NET: A review of norepinephrine transporter expression and efficacy of (131)I-mIBG therapy
title_full_unstemmed Nothing but NET: A review of norepinephrine transporter expression and efficacy of (131)I-mIBG therapy
title_short Nothing but NET: A review of norepinephrine transporter expression and efficacy of (131)I-mIBG therapy
title_sort nothing but net: a review of norepinephrine transporter expression and efficacy of (131)i-mibg therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237663/
https://www.ncbi.nlm.nih.gov/pubmed/25175627
http://dx.doi.org/10.1002/pbc.25200
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