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Codon optimization and factorial screening for enhanced soluble expression of human ciliary neurotrophic factor in Escherichia coli

BACKGROUND: Neurotrophic factors influence survival, differentiation, proliferation and death of neuronal cells within the central nervous system. Human ciliary neurotrophic factor (hCNTF) has neuroprotective properties and is also known to influence energy balance. Consequently, hCNTF has potential...

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Detalles Bibliográficos
Autores principales:	Itkonen, Jaakko M, Urtti, Arto, Bird, Louise E, Sarkhel, Sanjay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237735/ https://www.ncbi.nlm.nih.gov/pubmed/25394427 http://dx.doi.org/10.1186/s12896-014-0092-x

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