Reproducibility of exhaled nitric oxide measurements in overweight and obese adults

BACKGROUND: Exhaled nitric oxide is a noninvasive measure of airway inflammation that can be detected by a handheld device. Obesity may influence the reproducibility of exhaled nitric oxide measurements, by - for instance – decreased expiratory reserve volume. FINDINGS: We analyzed triple exhaled ni...

Descripción completa

Detalles Bibliográficos
Autores principales: Thijs, Willemien, de Mutsert, Renée, le Cessie, Saskia, Hiemstra, Pieter S, Rosendaal, Frits R, Middeldorp, Saskia, Rabe, Klaus F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237750/
https://www.ncbi.nlm.nih.gov/pubmed/25366981
http://dx.doi.org/10.1186/1756-0500-7-775
Descripción
Sumario:BACKGROUND: Exhaled nitric oxide is a noninvasive measure of airway inflammation that can be detected by a handheld device. Obesity may influence the reproducibility of exhaled nitric oxide measurements, by - for instance – decreased expiratory reserve volume. FINDINGS: We analyzed triple exhaled nitric oxide measurements from 553 participants (aged 45 to 65 years with a body mass index ≥27 kg/m(2)) of the Netherlands Epidemiology of Obesity Study. The interclass correlation coefficient (single measurement reliability) was 0.965 (95% CI: 0.960, 0.970). CONCLUSIONS: We conclude that for assessment of exhaled nitric oxide in large cohorts of overweight and obese adults a single measurement suffices.

Ejemplares similares