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Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer’s disease rats
Alzheimer’s disease (AD) is a most common age-related neurodegenerative disease. AD is characterized by a progressive loss of neurons causing cognitive dysfunction. The cerebellum is closely associated with integration of movement, including motor coordination, control, and equilibrium. In the prese...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Exercise Rehabilitation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237839/ https://www.ncbi.nlm.nih.gov/pubmed/25426461 http://dx.doi.org/10.12965/jer.140163 |
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author | Lee, Jae-Min Shin, Mal-Soon Ji, Eun-Sang Kim, Tae-Woon Cho, Han-Sam Kim, Chang-Ju Jang, Myung-Soo Kim, Tae-Wook Kim, Bo-Kyun Kim, Dong-Hee |
author_facet | Lee, Jae-Min Shin, Mal-Soon Ji, Eun-Sang Kim, Tae-Woon Cho, Han-Sam Kim, Chang-Ju Jang, Myung-Soo Kim, Tae-Wook Kim, Bo-Kyun Kim, Dong-Hee |
author_sort | Lee, Jae-Min |
collection | PubMed |
description | Alzheimer’s disease (AD) is a most common age-related neurodegenerative disease. AD is characterized by a progressive loss of neurons causing cognitive dysfunction. The cerebellum is closely associated with integration of movement, including motor coordination, control, and equilibrium. In the present study, we evaluated the effect of tread-mill exercise on the survival of Purkinje neurons in relation with reactive astrocyte in the cerebellum using Aβ(25–35)–induced AD rats. AD was induced by a bilateral intracerebroventricular (ICV) injection of Aβ(25–35). The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks, starting 2 days after Aβ(25–35) injection. In the present results, ICV injection of Aβ(25–35) deteriorated motor coordination and balance. The number of calbindin-positive cells in the cerebellar vermis was decreased and glial fibrillary acidic protein (GFAP) expression in the cerebellar vermis was increased in the Aβ(25–35)-induced AD rats. Treadmill exercise improved motor coordination and balance. Treadmill exercise increased the number of Purkinje neurons and suppressed GFAP expression in the cerebellar vermis. The present study demonstrated that treadmill exercises alleviated dysfunction of motor coordination and balance by reduction of Purkinje cell loss through suppressing reactive astrocytes in the cerebellum of AD rats. The present study provides the possibility that treadmill exercise might be an important therapeutic strategy for the symptom improvement of AD patients. |
format | Online Article Text |
id | pubmed-4237839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Society of Exercise Rehabilitation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42378392014-11-25 Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer’s disease rats Lee, Jae-Min Shin, Mal-Soon Ji, Eun-Sang Kim, Tae-Woon Cho, Han-Sam Kim, Chang-Ju Jang, Myung-Soo Kim, Tae-Wook Kim, Bo-Kyun Kim, Dong-Hee J Exerc Rehabil Original Article Alzheimer’s disease (AD) is a most common age-related neurodegenerative disease. AD is characterized by a progressive loss of neurons causing cognitive dysfunction. The cerebellum is closely associated with integration of movement, including motor coordination, control, and equilibrium. In the present study, we evaluated the effect of tread-mill exercise on the survival of Purkinje neurons in relation with reactive astrocyte in the cerebellum using Aβ(25–35)–induced AD rats. AD was induced by a bilateral intracerebroventricular (ICV) injection of Aβ(25–35). The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks, starting 2 days after Aβ(25–35) injection. In the present results, ICV injection of Aβ(25–35) deteriorated motor coordination and balance. The number of calbindin-positive cells in the cerebellar vermis was decreased and glial fibrillary acidic protein (GFAP) expression in the cerebellar vermis was increased in the Aβ(25–35)-induced AD rats. Treadmill exercise improved motor coordination and balance. Treadmill exercise increased the number of Purkinje neurons and suppressed GFAP expression in the cerebellar vermis. The present study demonstrated that treadmill exercises alleviated dysfunction of motor coordination and balance by reduction of Purkinje cell loss through suppressing reactive astrocytes in the cerebellum of AD rats. The present study provides the possibility that treadmill exercise might be an important therapeutic strategy for the symptom improvement of AD patients. Korean Society of Exercise Rehabilitation 2014-10-31 /pmc/articles/PMC4237839/ /pubmed/25426461 http://dx.doi.org/10.12965/jer.140163 Text en Copyright © 2014 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Jae-Min Shin, Mal-Soon Ji, Eun-Sang Kim, Tae-Woon Cho, Han-Sam Kim, Chang-Ju Jang, Myung-Soo Kim, Tae-Wook Kim, Bo-Kyun Kim, Dong-Hee Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer’s disease rats |
title | Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer’s disease rats |
title_full | Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer’s disease rats |
title_fullStr | Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer’s disease rats |
title_full_unstemmed | Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer’s disease rats |
title_short | Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer’s disease rats |
title_sort | treadmill exercise improves motor coordination through ameliorating purkinje cell loss in amyloid beta23-35-induced alzheimer’s disease rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237839/ https://www.ncbi.nlm.nih.gov/pubmed/25426461 http://dx.doi.org/10.12965/jer.140163 |
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