AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment

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BACKGROUND: Aurora kinase A (AurkA) is over-expressed in melanoma and its inhibition has been observed to limit tumor growth, suggesting a potential role in melanoma treatment. METHODS: A human melanoma cell line with the B-RAF (V600E) mutation (A375mel) was exposed to B-RAF inhibitor (GSK2118436),...

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Detalles Bibliográficos
Autores principales: Caputo, Emilia, Miceli, Roberta, Motti, Maria Letizia, Taté, Rosarita, Fratangelo, Federica, Botti, Gerardo, Mozzillo, Nicola, Carriero, Maria Vincenza, Cavalcanti, Ernesta, Palmieri, Giuseppe, Ciliberto, Gennaro, Pirozzi, Giuseppe, Ascierto, Paolo Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237855/
https://www.ncbi.nlm.nih.gov/pubmed/25074438
http://dx.doi.org/10.1186/s12967-014-0216-z
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