Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. Thus, a protective action has bee...

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Detalles Bibliográficos
Autores principales: Bulotta, Stefania, Celano, Marilena, Lepore, Saverio Massimo, Montalcini, Tiziana, Pujia, Arturo, Russo, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237885/
https://www.ncbi.nlm.nih.gov/pubmed/25086598
http://dx.doi.org/10.1186/s12967-014-0219-9
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author Bulotta, Stefania
Celano, Marilena
Lepore, Saverio Massimo
Montalcini, Tiziana
Pujia, Arturo
Russo, Diego
author_facet Bulotta, Stefania
Celano, Marilena
Lepore, Saverio Massimo
Montalcini, Tiziana
Pujia, Arturo
Russo, Diego
author_sort Bulotta, Stefania
collection PubMed
description The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. Thus, a protective action has been demonstrated in preclinical studies against several diseases, especially cardiovascular and metabolic disorders. The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds.
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spelling pubmed-42378852014-11-21 Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases Bulotta, Stefania Celano, Marilena Lepore, Saverio Massimo Montalcini, Tiziana Pujia, Arturo Russo, Diego J Transl Med Review The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. Thus, a protective action has been demonstrated in preclinical studies against several diseases, especially cardiovascular and metabolic disorders. The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds. BioMed Central 2014-08-03 /pmc/articles/PMC4237885/ /pubmed/25086598 http://dx.doi.org/10.1186/s12967-014-0219-9 Text en Copyright © 2014 Bulotta et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Bulotta, Stefania
Celano, Marilena
Lepore, Saverio Massimo
Montalcini, Tiziana
Pujia, Arturo
Russo, Diego
Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases
title Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases
title_full Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases
title_fullStr Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases
title_full_unstemmed Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases
title_short Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases
title_sort beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237885/
https://www.ncbi.nlm.nih.gov/pubmed/25086598
http://dx.doi.org/10.1186/s12967-014-0219-9
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