Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

BACKGROUND: Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO(2) coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following intratracheal (IT) instillation and gavage in rats. METHODS: Uncoated and Si...

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Detalles Bibliográficos
Autores principales: Konduru, Nagarjun V, Murdaugh, Kimberly M, Sotiriou, Georgios A, Donaghey, Thomas C, Demokritou, Philip, Brain, Joseph D, Molina, Ramon M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237897/
https://www.ncbi.nlm.nih.gov/pubmed/25183210
http://dx.doi.org/10.1186/s12989-014-0044-6

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