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The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid

BACKGROUND: Alzheimer’s disease (AD) is characterized by cerebral deposition of β-amyloid peptide (Aβ). Aβ is produced by sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Many studies have demonstrated that the internalization of APP from the cell surface can regula...

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Detalles Bibliográficos
Autores principales: Tam, Joshua HK, Seah, Claudia, Pasternak, Stephen H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237969/
https://www.ncbi.nlm.nih.gov/pubmed/25085554
http://dx.doi.org/10.1186/s13041-014-0054-1

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