Cargando…

Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release

Mitochondrial GTP (mtGTP)-insensitive mutations in glutamate dehydrogenase (GDH(H454Y)) result in fasting and amino acid–induced hypoglycemia in hyperinsulinemia hyperammonemia (HI/HA). Surprisingly, hypoglycemia may occur in this disorder despite appropriately suppressed insulin. To better understa...

Descripción completa

Detalles Bibliográficos
Autores principales: Kibbey, Richard G., Choi, Cheol Soo, Lee, Hui-Young, Cabrera, Over, Pongratz, Rebecca L., Zhao, Xiaojian, Birkenfeld, Andreas L., Li, Changhong, Berggren, Per-Olof, Stanley, Charles, Shulman, Gerald I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237996/
https://www.ncbi.nlm.nih.gov/pubmed/25024374
http://dx.doi.org/10.2337/db14-0783