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Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release

Mitochondrial GTP (mtGTP)-insensitive mutations in glutamate dehydrogenase (GDH(H454Y)) result in fasting and amino acid–induced hypoglycemia in hyperinsulinemia hyperammonemia (HI/HA). Surprisingly, hypoglycemia may occur in this disorder despite appropriately suppressed insulin. To better understa...

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Detalles Bibliográficos
Autores principales:	Kibbey, Richard G., Choi, Cheol Soo, Lee, Hui-Young, Cabrera, Over, Pongratz, Rebecca L., Zhao, Xiaojian, Birkenfeld, Andreas L., Li, Changhong, Berggren, Per-Olof, Stanley, Charles, Shulman, Gerald I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237996/ https://www.ncbi.nlm.nih.gov/pubmed/25024374 http://dx.doi.org/10.2337/db14-0783

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