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Increased Intraretinal PO(2) in Short-Term Diabetic Rats

In diabetic retinopathy, neovascularization is hypothesized to develop due to hypoxia in the retina. However, evidence for retinal hypoxia is limited, and the progressive changes in oxygenation are unknown. The objective of this study was to determine if retinal hypoxia occurs early in the developme...

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Detalles Bibliográficos
Autores principales: Lau, Jennifer C.M., Linsenmeier, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238003/
https://www.ncbi.nlm.nih.gov/pubmed/25028524
http://dx.doi.org/10.2337/db14-0101
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author Lau, Jennifer C.M.
Linsenmeier, Robert A.
author_facet Lau, Jennifer C.M.
Linsenmeier, Robert A.
author_sort Lau, Jennifer C.M.
collection PubMed
description In diabetic retinopathy, neovascularization is hypothesized to develop due to hypoxia in the retina. However, evidence for retinal hypoxia is limited, and the progressive changes in oxygenation are unknown. The objective of this study was to determine if retinal hypoxia occurs early in the development of diabetes. Intraretinal oxygen (PO(2)) profiles were recorded with oxygen-sensitive microelectrodes in control and diabetic Long-Evans rats at 4 and 12 weeks after induction of diabetes. Diabetes did not affect oxygen consumption in the photoreceptors in either dark or light adaptation. Oxygenation of the inner retina was not affected after 4 weeks of diabetes, although vascular endothelial growth factor levels increased. At 12 weeks, average inner retinal PO(2), normalized to choriocapillaris PO(2), was higher in diabetic rats than in age-matched controls, which was opposite to what was expected. Thus retinal hypoxia is not a condition of early diabetes in rat retina. Increased inner retinal PO(2) may occur because oxygen consumption decreases in the inner retina.
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spelling pubmed-42380032015-12-01 Increased Intraretinal PO(2) in Short-Term Diabetic Rats Lau, Jennifer C.M. Linsenmeier, Robert A. Diabetes Complications In diabetic retinopathy, neovascularization is hypothesized to develop due to hypoxia in the retina. However, evidence for retinal hypoxia is limited, and the progressive changes in oxygenation are unknown. The objective of this study was to determine if retinal hypoxia occurs early in the development of diabetes. Intraretinal oxygen (PO(2)) profiles were recorded with oxygen-sensitive microelectrodes in control and diabetic Long-Evans rats at 4 and 12 weeks after induction of diabetes. Diabetes did not affect oxygen consumption in the photoreceptors in either dark or light adaptation. Oxygenation of the inner retina was not affected after 4 weeks of diabetes, although vascular endothelial growth factor levels increased. At 12 weeks, average inner retinal PO(2), normalized to choriocapillaris PO(2), was higher in diabetic rats than in age-matched controls, which was opposite to what was expected. Thus retinal hypoxia is not a condition of early diabetes in rat retina. Increased inner retinal PO(2) may occur because oxygen consumption decreases in the inner retina. American Diabetes Association 2014-12 2014-11-13 /pmc/articles/PMC4238003/ /pubmed/25028524 http://dx.doi.org/10.2337/db14-0101 Text en © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
spellingShingle Complications
Lau, Jennifer C.M.
Linsenmeier, Robert A.
Increased Intraretinal PO(2) in Short-Term Diabetic Rats
title Increased Intraretinal PO(2) in Short-Term Diabetic Rats
title_full Increased Intraretinal PO(2) in Short-Term Diabetic Rats
title_fullStr Increased Intraretinal PO(2) in Short-Term Diabetic Rats
title_full_unstemmed Increased Intraretinal PO(2) in Short-Term Diabetic Rats
title_short Increased Intraretinal PO(2) in Short-Term Diabetic Rats
title_sort increased intraretinal po(2) in short-term diabetic rats
topic Complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238003/
https://www.ncbi.nlm.nih.gov/pubmed/25028524
http://dx.doi.org/10.2337/db14-0101
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